Skip to main content

Advertisement

SpringerLink
Log in

Modulation of nucleic acid information processing by PNAs: potential use in anti-viral therapeutics

  • Published:
Letters in Peptide Science Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Nielsen, P.E., Egholm, M. and Berg, R.H. et al., Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide. Science, 254 (1991) 1497.

    CAS  PubMed  Google Scholar 

  2. Egholm, M., Buchardt, O. and Christensen, L. et al., PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen-bonding rules. Nature., 365 (1993) 566.

    Article  CAS  PubMed  Google Scholar 

  3. Demidov, V.V., Potaman, V.N. and Frank-Kamenetskii, M.D. et al., Stability of peptide nucleic acids in human serum and cellular extracts. Biochem. Pharmacol., 48 (1994) 1310.

    CAS  Google Scholar 

  4. Hanvey, J.C., Peffer, N.J. and Bisi, J.E. et al., Antisense and antigene properties of peptide nucleic acids. Science, 258 (1992) 1481.

    CAS  PubMed  Google Scholar 

  5. Peffer, N.J. Hanvey, J.C. and Bisi, J.E. et al. Strand-invasion of duplex DNA by peptide nucleic acid oligomers. Proc. Natl. Acad. Sci. USA, 90 (1993) 10648.

    CAS  PubMed  Google Scholar 

  6. Knudsen, H. and Nielsen, P.E. Antisense properties of duplex-and triplex-forming PNAs. Nucleic Acids Res., 24 (1996) 494.

    Article  CAS  PubMed  Google Scholar 

  7. Boffa, L.C., Scarfi, S. and Mariani, M.R. et al., Di-hydrotestosterone as a selective cellular/nuclear localization vector for anti-gene peptide nucleic acid in prostatic car-cinoma cells. Cancer Res., 60 (2000) 2258.

    CAS  PubMed  Google Scholar 

  8. Zhang, X., Simmons, C.G. and Corey, D.R. Liver cell spe-cific targeting of peptide nucleic acid oligomers. Bioorg. Med. Chem. Lett., 11 (2001) 1269. (Eng).

    CAS  PubMed  Google Scholar 

  9. Cutrona, G., Carpaneto, E.M. and Ulivi, M., et al. Effects in live cells of a c-myc anti-gene PNA linked to a nuclear localization signal. Nat. Biotechnol., 18 (2000) 300.

    CAS  PubMed  Google Scholar 

  10. Pooga, M., Soomets, U. and Hallbrink, M., et al. Cell pen-etrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivo. Nat. Biotechnol., 16 (1998) 857.

    Article  CAS  PubMed  Google Scholar 

  11. Villa, R., Folini, M. and Lualdi, S. et al. Inhibition of te-lomerase activity by a cell-penetrating peptide nucleic acid construct in human melanoma cells. FEES Lett., 473 (2000) 241.

    Article  CAS  Google Scholar 

  12. Zamaratski, E., Pradeepkumar, P.I. and Chattopadhyaya, J.A. critical survey of the structure-function of the antis-ense oligo/RNA heteroduplex as sub-strate for RNase H. J. Biochem. Biophys. Methods, 48 (2001) 189.

    Article  CAS  PubMed  Google Scholar 

  13. Bielinsky, A.K. and Gerbi, S.A. Where it all starts: eukaryotic origins of DNA replication. J. Cell. Sci., 114 (2001) 643.

    CAS  PubMed  Google Scholar 

  14. Dvir, A., Conaway, J.W. and Conaway, R.C. Mechanism of transcription initiation and promoter escape by RNA poly-merase II. Curr. Opin. Genet. Dev., 11 (2001) 209.

    Article  CAS  PubMed  Google Scholar 

  15. Kozak, M. Initiation of translation in prokaryotes and euka-ryotes. Gene, 234 (1999) 187.

    Article  CAS  PubMed  Google Scholar 

  16. Edwards, A.M. Bochkarev, A. and Frappier, L. Origin DNA-binding proteins. Curr. Opin. Struct. Biol., 8 (1998) 49.

    Article  CAS  PubMed  Google Scholar 

  17. Kurg, R., Langel, U. and, Ustav, M. Inhibition of the bovine papillomavirus E2 protein activity by peptide nucleic acid. Virus Res., 66 (2000) 39.

    Article  CAS  PubMed  Google Scholar 

  18. Birg, F., Praseuth, D. and Zerial, A. et al., Inhibition of simian virus 40 DNA replication in CV-1 cells by an oligodeoxy-nucleotide covalently linked to an intercalating agent. Nucleic Acids Res., 18 (1990) 2901.

    CAS  PubMed  Google Scholar 

  19. Praseuth, D., Grigoriev, M. and Guieysse, A.L. et al., Peptide nucleic acids directed to the promoter of the alpha-chain of the interleukin-2 receptor. Biochim. Biophys. Acta, 1309 (1996) 226.

    CAS  PubMed  Google Scholar 

  20. Vickers, T.A. Griffith, M.C. and Andamasamy, K., et al., Inhibi-tion of NF-kappa B specific transcriptional activation by PNA strand invasion. Nucleic Acids Res., 23 (1995) 3003.

    CAS  PubMed  Google Scholar 

  21. Duval-Valentin, G. Thuong, N.T. and Helene, C. Specific inhibition of transcription by triple helix-forming oligonuc-leotides. Proc. Natl. Acad. Sci. USA., 89 (1992) 504 (Eng).

    CAS  PubMed  Google Scholar 

  22. Mologni, L., Marchesi, E. and Nielsen, P.E. et al. Inhibition of promyelocytic leukemia (PML)/retinoic acid receptor-alpha and PML expression in acute promyelocytic leukemia cells by anti-PML peptide nucleic acid. Cancer Res., 61 (2000) 5468.

    Google Scholar 

  23. Mologni, L. leCoutre, P. and Nielsen, P.E. et al. Additive antis-ense effects of different PNAs on the in vitrotranslation of the PML/RARalpha gene. Nucleic Acids Res., 26 (1998) 1934.

    Article  CAS  PubMed  Google Scholar 

  24. Doyle, D.F., Braasch, D.A. and Simmons, C.G. et al. Inhibi-tion of gene expression inside cells by peptide nucleic acids: effect of mRNA target sequence, mismatched bases, and PNA length. Biochem., 40 (2000) 53.

    Google Scholar 

  25. Nielsen, P.E., Egholm. M. and Berg, R.H. et al., Peptide nuc-leic acids (PNAs): potential antisense and anti-gene agents. Anticancer Drug Des., 8 (1993) 53.

    CAS  PubMed  Google Scholar 

  26. Taylor, R.W., Chinnery, P.F. and Turnbull, D.M. et al. Select-ive inhibition of mutant human mitochondrial DNA replica-tion in vitroby peptide nucleic acids. Nat. Genet., 15 (1997) 212.

    Article  CAS  PubMed  Google Scholar 

  27. Muratovska, A., Lightowlers, R.N. and Taylor, R.W. et al., Targeting peptide nucleic acid (PNA) to diagramers mito-chondria within cells by conjugation to lipophilic cations: implications for mitochondrial DNA replication, expression and disease. Nucleic Acids Res., 29 (2001) 1852.

    Article  CAS  PubMed  Google Scholar 

  28. Nielsen, P.E., Egholm, M. and Buchardt, O. Sequence-specific transcription arrest by peptide nucleic acid bound to the DNA template strand. Gene, 149 (1994) 139, (Eng).

    Article  CAS  PubMed  Google Scholar 

  29. Boffa, L.C., Morris, P.L. and Carpaneto, E.M. et al. Invasion of the CAG triplet repeats by a complementary peptide nuc-leic acid inhibits transcription of the androgen receptor and TATA-binding protein genes and correlates with refolding of an active nucleosome containing a unique AR gene sequence. J. Biol. Chem., 271 (1996) 13228.

    CAS  PubMed  Google Scholar 

  30. Gee, J.E., Robbins, I. and van der Laan, A.C. et al., Assessment of high-affinity hybridization, RNase H cleavage, and covalent linkage in translation arrest by antisense oligo-nucleotides. Antisense Nucl. Acid Drug Dev., 8 (1998) 103 (Eng).

    CAS  Google Scholar 

  31. Bias, N., Dheur, S. and Nielsen, P.E. et al., Antisense PNA tridecamers targeted to the coding region of Ha-ras mRNA arrest polypeptide chain elongation. J. Mol. Biol., 294 (1999) 403.

    Google Scholar 

  32. Alberts, B.M. The DNA enzymology of protein machines. Cold Spring Harb Symp. Quant. Biol., 49 (1984) 1.

    CAS  Google Scholar 

  33. Lohman, T.M. and Bjornson, K.P. Mechanisms of helicase-catalyzed DNA unwinding. Annu. Rev. Biochem., 65 (1996) 169.

    Article  CAS  PubMed  Google Scholar 

  34. Kopel, V., Pozner, A. and Baran, N. et al. Unwinding of the third strand of a DNA triple helix, a novel activity of the SV40 large T-antigen helicase. Nucleic Acids Res., 24 (1996) 330.

    Article  CAS  PubMed  Google Scholar 

  35. Maine, I.P. and Kodadek, T. Efficient unwinding of triplex DNA by a DNA helicase. Biochem. Biophys. Res. Commun., 204 (1994) 1119.

    Article  CAS  PubMed  Google Scholar 

  36. Bastide, L., Boehmer, P.E. and Villani, G. et al. Inhibition of a DNA-helicase by peptide nucleic acids. Nucleic Acids Res., 27 (1999) 551.

    Article  CAS  PubMed  Google Scholar 

  37. Boehmer, P.E. and Lehman, I.R. Herpes simplex virus DNA replication. Annu. Rev. Biochem., 66 (1997) 347.

    Article  CAS  PubMed  Google Scholar 

  38. Tackett, A.J., Wei, L. and Cameron, C.E. et al. Unwinding of nucleic acids by HCV NS3 helicase is sensitive to the structure of the duplex. Nucleic Acids Res., 29 (2001) 565.

    Article  CAS  PubMed  Google Scholar 

  39. Tackett, A.J., Morris, P.D. and Dennis, R. et al. Unwinding of unnatural sub-strates by a DNA helicase. Biochem., 40 (2001) 543.

    CAS  Google Scholar 

  40. Died, G., Corradini, R. and Sforza, S. et al. Inhibition of RNA polymerase III elongation by a T10 peptide nucleic acid. J. Biol. Chem., 276 (2001) 5720.

    Google Scholar 

  41. Bentin, T. and Nielsen, P.E. Enhanced peptide nucleic acid binding to supercoiled DNA: possible implications for DNA breathing dynamics. Biochem., 35 (1996) 8863.

    CAS  Google Scholar 

  42. Wahle, E. and Ruegsegger, U. 3-End processing of pre-mRNA in eukaryotes. FEMS Microbiol. Rev., 23 (1999) 277.

    CAS  PubMed  Google Scholar 

  43. Vickers, T.A., Wyatt, J.R. and, Burckin, T. et al. Fully modified 2 MOE oligonucleotides redirect polyadenylation. Nucleic Acids Res., 29 (2001) 1293.

    Article  CAS  PubMed  Google Scholar 

  44. Horowitz, D.S. and Krainer, A.R. Mechanisms for selecting 5 splice sites in mammalian pre-mRNA splicing. Trends Genet., 10 (1994) 100.

    Article  CAS  PubMed  Google Scholar 

  45. Sierakowska, H., Sambade, M.J. and Schumperli, D. et al., Sensitivity of splice sites to antisense oligonucleotides in vivo. RNA, 5 (1999) 369.

    Article  CAS  PubMed  Google Scholar 

  46. Lacerra, G., Sierakowska, H. and Carestia, C. et al.Res-toration of hemoglobin A synthesis in erythroid cells from peripheral blood of thalassemic patients. Proc. Natl. Acad. Sci. USA, 97 (2000) 9591.

    Article  CAS  PubMed  Google Scholar 

  47. Karras, J.G., Maier, M.A. and Lu, T. et al. Peptide nucleic acids are potent modulators of endogenous pre-mrna splicing of the murine interleukin-5 receptor-alpha chain. Biochem., 40 (2001) 7853.

    CAS  Google Scholar 

  48. Lee, R., Kaushik, N. and Modak, M.J. et al. Polyamide nuc-leic acid targeted to the primer binding site of the HIV-1 RNA genome blocks in vitro HIV-1 reverse transcription. Biochem. 37 (1998) 900.

    CAS  Google Scholar 

  49. Boulme, F., Freund, F. and Moreau, S. et al. Modified (PNA, 2-O-methyl and phosphoramidate) anti-TAR antisense oligo-nucleotides as strong and specific inhibitors of in vitroHIV-1 reverse transcription. Nucleic Acids Res., 26 (1998) 5492.

    Article  CAS  PubMed  Google Scholar 

  50. Mouscadet, J.F., Carteau, S. and Goulaouic, H. et al.Triplex-mediated inhibition of HIV DNA integration in vitro. J. Biol. Chem., 269 (1994) 21635.

    CAS  PubMed  Google Scholar 

  51. Bouziane, M., Cherny, D.I., Mouscadet, J.F. et al., Alternate strand DNA triple helix-mediated inhibition of HIV-1 U5 long terminal repeat integration in vitro. J. Biol. Chem., 271 (1996) 10359.

    CAS  PubMed  Google Scholar 

  52. Mayhood, T., Kaushik, N. and Pandey, P.K. et al., Inhibition of Tat-mediated transactivation of HIV-1 LTR transcription by polyamide nucleic acid targeted to TAR hairpin element. Biochem., 39 (2000) 11532.

    CAS  Google Scholar 

  53. Vickers, T.A. and Ecker, D.J. Enhancement of ribosomal frameshifting by oligonucleotides targeted to the HIV gag-pol region. Nucleic Acids Res., 20 (1992) 3945.

    CAS  PubMed  Google Scholar 

  54. Lodmell, J.S., Ehresmann, C. and Ehresmann, B. et al.Struc-ture and dimerization of hiv-1 kissing loop aptamers. J. Mol. Biol., 311 (2001) 475.

    Article  CAS  PubMed  Google Scholar 

  55. Zennoum V., Petit, C. and Guetard, D. et al., HIV-1 genome nuclear import is mediated by a central DNA flap. Cell, 101 (2000) 173.

    Google Scholar 

  56. Hiratou, T., Tsukahara, S. and Miyano-Kurosaki, N. et al.In-hibition of HIV-1 replication by a two-strand system (FTFOs) targeted to the polypurine tract. FEES Lett., 456 (1999) 186.

    Article  CAS  Google Scholar 

  57. Faria, M., Wood, C.D. and Perrouault, L. et al., Targeted inhibition of transcription elongation in cells mediated by triplex-forming oligonucleotides. Proc. Natl. Acad. Sci. USA, 97 (2000) 3862.

    Article  CAS  PubMed  Google Scholar 

  58. Malchere, C., Verheijen, J. and van der Laan, S. et al.A short phosphodiester window is sufficient to direct RNase H-.159 dependent RNA cleavage by antisense peptide nucleic acid. Antisense Nucleic Acid Drug. Dev., 10 (2000) 463.

    CAS  PubMed  Google Scholar 

  59. Verheijen, J.C., Chen, L. and Bayly, S.F. et al. Synthesis and RNAse L binding and activation of a 2-5A-(5 )-DNA-(3 )-PNA chimera, a novel potential antisense molecule. Nucleos-ides Nucleotides Nucleic Acids, 19 (2000) 1821.

    CAS  Google Scholar 

  60. Verheijen, J.C., van der Marel, G.A. and van Boom, J.H. et al. 2,5-oligoadenylatepeptide nucleic acids (2-5A-PNAs) activate RNase L. Bioorg. Med. Chem., 7 (1999) 449.

    CAS  PubMed  Google Scholar 

  61. Verheijen, J.C., Bayly, S.F. and Player, M.R. et al.2-5A-PNA complexes: a novel class of antisense compounds. Nucleosides Nucleotides, 18 (1999) 1485.

    CAS  PubMed  Google Scholar 

  62. Wang, Z., Chen, L. and Bayly, S.F. et al. Convergent synthesis of ribonuclease L-active 2, 5-oligoadenylate-peptide nucleic acids. Bioorg. Med. Chem. Lett., 10 (2000) 1357.

    CAS  PubMed  Google Scholar 

  63. Bigey, P., Sonnichsen, S.H. and Meunier, B. et al. DNA bind-ing and cleavage by a cationic manganese porphyrin-peptide nucleic acid conjugate. Bioconjug. Chem., 8 (1997) 267.

    Article  CAS  PubMed  Google Scholar 

  64. Footer, M., Egholm, M. and Kron, S. et al. Biochemical evidence that a D-loop is part of a four-stranded PNA-DNA bundle. Nickel-mediated cleavage of duplex DNA by a Gly-Gly-His bis-PNA. Biochem., 35 (1996) 10673.

    CAS  Google Scholar 

  65. Armitage, B., Koch, T. and Frydenlund, H. et al., Peptide nucleic acidanthraquinone conjugates: strand invasion and photoinduced cleavage of duplex DNA. Nucleic Acids Res., 25 (1997) 4674.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. UMR 5124, IGMM, Centre National de la Recherche Scientifique &, Universite Montpellier 2, Montpellier, France

    Lionel Bastide, Bernard Lebleu & Ian Robbins

Authors
  1. Lionel Bastide
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bernard Lebleu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ian Robbins
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bastide, L., Lebleu, B. & Robbins, I. Modulation of nucleic acid information processing by PNAs: potential use in anti-viral therapeutics. Int J Pept Res Ther 10, 149–159 (2003). https://doi.org/10.1007/s10989-004-4923-9

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10989-004-4923-9

Keywords

Search

Navigation