Skip to main content
Log in

A new method for localised spinal-cord cooling

  • Published:
Medical and biological engineering Aims and scope Submit manuscript

Abstract

Hypothermia reduces ischaemic damage to nervous tissue and decreases cerebral oedema. Selective spinal-cord cooling has therefore been proposed as a means of treatment in spinalcord trauma. A miniature heat exchanger, made of Silastic, has been developed that can rapidly induce a central cord temperature of 17°C and may be left in place for several days without complication.

Sommaire

L'hypothermie a pour effet de réduire aussi bien les dégradations occasionnées au tissu nerveux par l'ischémie que l'incidence d'oedèmes cérébraux. Le refoidissement sélectif de la moelle épinière a donc éte proposé comme moyen de traitement dans les cas de trauma du cordon médullaire. Un échangeur de chaleur miniature en ‘Silastic’ a été mis au point qui peut produire rapidement une température de 17°C au niveau du cordon médullaire et qui peut être laissé en place pendant plusieurs jours sans entraîner de complications.

Zusammenfassung

Unterkühlung verringert eine Ischämieschädigung des Nervengewebes und mindert Hirnödeme. Zur Behandlung von Rückenmarksverletzungen wird daher selektive Kühlung vorgeschlagen. Ein aus Silastic bestehender Miniaturwärmeaustauscher ist entwickelt worden, der die Temperatur im Zentrum des Rückenmarks schnell auf 17°C senkt und mehrere Tage ohne Komplikationen im Körper verbleiben kann.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Albin, M. S., White, R. J., Acosta-Rua, G. andYashon D. (1968) Study of functional recovery produced by delayed localized cooling after spinal cord injury in primates.J. Neurosurg.29, 113–120.

    Google Scholar 

  • Albin, M. S., White, R. J. andMacCarthy, C. S. (1963) Effects of perfusion cooling of the subarachnoid space.Anaesthesiology24, 72–80.

    Google Scholar 

  • Albin, M. S., White, R. J., Locke, G. S., Massopust, L. C. Jr. andKretchner, H. E. (1967) Localized spinal cord hypothermia, anaesthetic effects and application to spinal cord injury.Anaesthesia and Analgesia46, 8–16.

    Article  Google Scholar 

  • Allen, A. R. (1914) Remarks on the histopathological changes in the spinal cord due to impact: An experimental study.J. Nerv. Ment. Dis.41, 141–147.

    Article  Google Scholar 

  • Bigelow, W. F., Lindsay, W. K. andGreenwood, W. F. (1950) Hypothermia—Its possible role in cardiac surgery: investigation of factors governing survival in dogs at low body temperatures.Ann. Surg.132, 849–866.

    Google Scholar 

  • Dohrmann, G. J., Wagner, F. C. Jr. andBucy, P. C. (1971) The microvasculature in transitory traumatic paraplegia. An electron microscopic study in the monkey.J. Neurosurg.35, 263–271.

    Google Scholar 

  • Ducker, T. B. andHamit, H. F. (1969) Experimental treatments of acute spinal cord injury.J. Neurosurg.30, 693–697.

    Article  Google Scholar 

  • Hansebout, R. R., Lewin, M. G. andPappius, H. M. (1972) Evidence regarding the action of steroids in injured spinal cord. In:Steroids and Brain Edema. Eds.H. J. Reulen andK. Schurmann. Springer-Verlag, New York, 153–155.

    Google Scholar 

  • Hegnauer, A. H. (1959) Lethal hypothermic temperatures for dog and man.Ann. N.Y. Acad. Sci.80, 315–319.

    Google Scholar 

  • Kelly, D. L. Jr., Lassiter, K. R. L., Calogero, J. A. andAlexander, E. Jr. (1970) Effects of local hypothermia and tissue oxygen studies in experimental paraplegia.J. Neurosurg.33, 554–563.

    Article  Google Scholar 

  • Lewin, M. G., Pappius, H. M. andHansebout, R. R. (1972) Effects of steroids on edema associated with injury of the spinal cord. In:Steroids and Brain Edema. Eds.H. J. Reulen andK. Schurmann. Springer-Verlag, New York, 101–112.

    Google Scholar 

  • McQueen, J. D. andJeanes, R. D. (1962) Influence of hypothermia on intracranial hypertension.J. Neurosurg.19, 277–288.

    Google Scholar 

  • Negrin, J. Jr. (1962) Prévention des lésions de la moelle épiniére par l'hypothermia régionale extravasculaire.Révue Neurologique106, 725–729.

    Google Scholar 

  • Negrin, J. Jr. (1966) Local hypothermia of the spinal cord for relief of spasticity and rigidity: Preliminary observation.Arch. Phys. Med. & Rehab.47, 169–173.

    Google Scholar 

  • Negrin, J. Jr. (1970) The hypothermostat: An instrument to obtain local hypothermia of the brain or spinal cord.Int. Surg.53, 93–106.

    Google Scholar 

  • Richardson, H. D. andNakamura, S. (Apr. 20, 1971) An electron microscopic study of spinal cord edema and the effect of treatment with steroids, Mannitol and hypothermia. Presented at the American Association of Neurological Surgeons. Houston, Texas, USA.

  • Scarff, J. E. (1960) Injuries of the vertebral column and spinal cord. In:Injuries of the spinal cord and their coverings.Brock, S. Editor. Fourth Edn, New York, Springer Publishing Co. 530–589.

    Google Scholar 

  • Tarlov, I. M. (1955) Spinal cord injuries—early treatment. The Surgical Clinics of North America. 591–607.

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Romero-Sierra, C., Sierhuis, A., Hansebout, R. et al. A new method for localised spinal-cord cooling. Med. & biol. Engng. 12, 188–193 (1974). https://doi.org/10.1007/BF02477154

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02477154

Keywords

Navigation