Abstract
This report concerns a clinical evaluation for a newly devised hollow fiber oxygenator, Capiox II. It functions on a one-pump system, and is simple to set up and operate. This equipment was used for 118 patients undergoing cardiac surgery at Tokyo University Hospital from February 1982 through February 1983. The gas transfer capacity proved to be satisfactory. The employment of an air-oxygen blender prevented overoxygenation, and reasonable levels of PaO2 and PaCO2 were demonstrated with a FiO2 0.7,\(\dot V/\dot Q\) ratio 0.7 at normothermia. The destruction of platelets was much less with the use of this oxygenator, as compared to findings with the BOS-10. Hemolysis by Capiox II appeared to be lower than that by BOS-10, but the difference was not statistically significant. Differences were distinct in the amount of microbubbles; strikingly, no bubble was evidenced in Capiox II by the ultrasound bubble detector, during general procedures. We conclude that Capiox II is of excellent clinical value, and should be used especially for infants as well as adult patients with possible long perfusions. The merits and demerits of this equipment are given attention.
Similar content being viewed by others
References
Tsuji T, Suma K, Takeuchi Y, Inoue K, Shiroma K, Yoshikawa T, Narumi J, Itoh N, Kobayashi H, Mori K, Fukazawa H, Tanishita K. Animal test and clinical application of newly developed hollow fiber oxygenator for open heart surgery. Jinkoh Zohki (Jpn Artificial Organs) 1980; 9: 551–553. (English abstract)
Sum K, Tsuji T, Takeuchi Y, Inoue K, Shiroma K, Yoshikawa T, Narumi J. Clinical performance of microporous polypropylene hollow-fiber oxygenator. Ann Thorac Surg 1981; 32: 558–562.
Monzen T, Ohe A, Fukasawa H, Hasegawa H, Kanno M, Takahashi A, Tsuji T, Suma K. Development on a device of supplying mixed gas for membrane oxygenator. Jinkoh Zohki (Jpn Artificial Organs) 1981; 10: 183–186. (English abstract)
Gibbon JH Jr. Application of a mechanical heart and lung apparatus to cardiac surgery. Minnesota Medicine 1954; 37: 171–177.
Lillehei CW, DeWall RA, Read RC, Warden HE, Varco RL. Direct vision intracardiac surgery in man using a simple, disposable artificial oxygenator. Diseases of the Chest 1956; 29: 1–8.
Kay EB, Zimmermann HA, Burne RM, Hirose Y, Jones RD, Cross FS. Certain clinical aspects of the use of a pump-oxygenator. JAMA 1956; 162: 639–641.
Osborn JJ, Cohn K, Hait M, Russi M, Salel A, Harkins G, Gerbode F. Hemolysis during perfusion. Sources and means of reduction. J Thorac Cardiovasc Surg 1962; 43: 459–464.
Lee WH Jr, Krumhaar D, Fonkalsrud EW, Schjeide OA, Maloney JV Jr. Denaturation of plasma proteins as a cause of morbidity and death after intracardiac operations. Surgery 1961; 50: 29–39.
Muraoka R, Yokota M, Aoshima M, Kyoku I, Nomoto S, Kobayashi A, Nakano H, Ueda K, Saito A, Hojo H. Subclinical changes in brain morphology following cardiac operations as reflected by computed tomographic scan of the brain. J Thorac Cardiovasc Surg 1981; 81: 364–369.
Carlson RC, Landé AJ, Twitchell J. Prolonged cardiopulmonary support with disposable membrane oxygenator during aorto coronary bypass grafts. NY State J Med 1972; 72: 2513–2518.
Chopra PS, Dufek JH, Kroncke GM, Dacumos GC, Celesia GG, Troner SP, Maschall JR, Jefferson JW, Loring LL, Kahn DR. Clinical comparison of the General Electric-Peirce Membrane lung and bubble oxygenator for prolonged cardiopulmonary bypass. Surgery 1973; 74: 874–879.
Beall AC, Solis RT, Kakvan M, Morris GC Jr, Noon GP, DeBakay, ME. Clinical experience with the Teflo disposable membrane oxygenator. Ann Thorac Surg 1976; 21: 144–150.
Hessel EA, Johnson DD, Ivey TD, Miller DW. Membrane versus bubble oxygenator for cardiac operations. A prospective randomized study. J Thorac Cardiovasc Surg 1980; 80: 111–122.
Kolobow T, Bowman RL. Construction and evaluation of an alveolar membrane artificial heart lung. Trans Amer Soc Artif Int Organs 1963; 9: 238–243.
Saxena NC, Hillyer P, Edmunds LH Jr. Use of the spiral coil membrane oxygenator during open heart surgery in infants and children. J Cardiovasc Surg 1977; 18: 1–7.
Valdes F, Meserko J, Sinkewich M, Malchesky P, Kambic H, Harasaki H, Golding L, Nose Y. A new hollow fiber membrane oxygenator for adult cardiopulmonary bypass. Artificial Organs 1981; 5 (Suppl.): 813–816.
Pollard HS Jr, Fleischaker RJ, Timmers JJ, Karlson KE. Blood-brain barrier studies in extracorporeal cooling and warming. J Thorac Cardiovasc Surg 1961; 42: 772–781.
Ito I, Kolff WJ, Effler DB. Prevention of overoxygenation during treatment with a heart-lung machine in cardiac operations. Cleveland Clin Quart 1958; 25: 9–17.
Mengel CE, Kann HE. Effects of in vivo hyperoxia on erythrocytes. III. In vivo peroxidation of erythrocyte lipid. J Clin Invest 1966; 45: 1150–1158.
Matthews EC, Clark LC, Edwards FK, Kaplan S, Helmsworth JA. Studies during the immediate postoperative period following total body perfusion. Arch Surg 1958; 77: 313–318.
Liddicoat JE, Bekassy SM, Beall AC, Glaeser DH, DeBakey ME. Membrane vs bubble oxygenator. Clinical comparison. Ann Surg 1975; 181: 747–753.
Bartlett RH, Fong SW, Woldanski C, Hung E, Styler D, MacArther C. Hematologic responses to prolonged extractorporeal circulation (ECC) with microporous membrane oxygenator. Trans Amer Soc Artif Int Organs 1975; 21: 250–256.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Makuuchi, H., Mizuno, A., Furuse, A. et al. Clinical evaluation of the microporous hollow fiber oxygenator. The Japanese Journal of Surgery 14, 387–393 (1984). https://doi.org/10.1007/BF02469546
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02469546