Abstract
The treatment of gallbladder malignancy has been rather unrewarding because of the difficulty in establishing diagnosis in early stage. A review of 34 cases of malignant gallbladder neoplasm encountered during the past 17 years has been made in order to aide diagnosis by careful evaluation of the case history, presenting signs, laboratory findings and radiological studies. Tenderness and a mass in right upper quadrant and nonvisualization of the gallbladder by cholecystography seem to be the most frequent presenting signs for suspecting gallbladder malignancy. Recent advance of celiac angiography seems to hold promise in establishing preoperative diagnosis thus allowing initiation of early effective treatment.
Similar content being viewed by others
References
Abrams, R. M., Meng, C. H., Firooznia, H., Beranbaum, E. R., and Epstein, H. Y.: Angiographic demonstration of carcinoma of the gallbladder, Radiology, 94: 277–282, 1970.
Barrett, O., and Cohen, A.: Liver regeneration after major hepatectomy. Effect of chemotherapy on growth and function-case report, Cancer, 22: 268–273, 1968.
Burckhart, T. and Loew, D.: Das Karzinom der Gallenblase und der Gallenwege. Bruns. Beitr. Klin. Chir., 214: 314–337, 1967.
Fahim, R. B., McDonald, J. R., Richards, J. C. and Ferris, D. O.: Carcinoma of the gallbladder, A study of its modes of spread, Ann. Surg., 156: 114–124, 1962.
Friedman, I. H., Mehler, G. and Ginzburg, L.: Pyloroduodenal obstruction due to carcinoma of the gallbladder, Amer. J. Gastroent., 52: 224–230, 1969.
Glenn, F. and Haye, D. M.: The age factor in the mortality rate of patients undergoing surgery of the biliary tract, Surg. Gynec. Obstet., 100: 11–18, 1955.
Hardy, M. A. and Volk, H.: Primary carcinoma of the gallbladder. A ten year review, Amer. J. Surg., 120: 800–803, 1971.
Hart, J., Modan, B. and Shani, M.: Cholelithiasis in the aetiology of gallbladder neoplasms, Lancet, 1: 1151–1153, 1971.
Holmes, S. L. and Mark, J. B. D.: Carcinoma of the gallbladder, Surg. Gynec. Obstet., 133: 561–564, 1971.
Katayama, H., Tanaka, M., Nakayama, F. and Wakita, M.: Two cases of gallbladder cancer diagnosed preoperatively by celiac angiography, Rinsho Hoshasen (Jap. J. Clin. Radiol.) 17: 139–144, 1972 (in Japanese).
Keill, R. H. and De Wesse, M. S.: Primary carcinoma of the gallbladder, Amer. J. Surg., 125: 726–729, 1973.
Kido, C., Sasaki, T. and Kaneko, M.: Angiography of cancer of the gallbladder, Rinsho Hoshasen (Jap. J. Clin. Radiol.), 16: 63–69, 1971 (in Japanese).
Klein, J. B. and Finck, F. M.: Primary carcinoma of the gallbladder, Review of 28 cases, Arch. Surg., 104: 769–772, 1972.
Kotorac, V.: Biliary peritonitis resulting from a perforated carcinomatous gallbladder, a case report, Gastroenterology, 63: 328–330, 1972.
Kretzschmar, U. and Kunzelmann, F.: Als Ulcus duodeni fehlgedeuteter Einbruch eines Gallenblasenkarzinoms in den Bulbus duodeni, Dtsch. Gesundh. 28: 1005–1008, 1973.
McNalty, J. G.: Preoperative diagnosis of carcinoma of the gallbladder by percutaneous transhepatic cholangiography, Amer. J. Roentgen, 101: 605–607, 1973.
Mehrotra, T. N., Gupta S. C., Naithani, Y. P.: Carcinosarcoma of the gallbladder, J. Path., 104: 145–148, 1971.
Newman, H. F., Northup, Rosenblum, M. and Abrams, H.: Complications of cholelithiasis, Amer. J. Gastroent., 50: 476–496, 1968.
Ogoshi, K., Niwa, M., Hara, Y. and Nebel, O. T.: Endoscopic pancreatocholangiography in the evaluation of pancreatic and biliary disease, Gastroenterology, 64: 210–216, 1973.
Pemberton, L. B., Diffenbaugh, W. F. and Strohl, E. L.: The surgical significance of carcinoma of the gallbladder, Amer. J. Surg., 122: 381–383, 1971.
Ram, M. D.: Carcinoma of the gallbladder, Surg. Gynec. Obstet., 132: 1044–1048, 1971.
Ravinov, K.: Primary carcinoma in a functioning gallbladder, Gastroenterology, 50: 808–810, 1966.
Rissel, E. and Streubel, A.: Relations between gallbladder carcinoma, cholelithiasis and cholecystitis, Gastroenterology, 6: 375–381, 1968.
Roeder, W. J., Mersheimer, W. L. and Kazarian, K. K.: Triplication of the gallbladder with cholecystitis, cholelithiasis and papillary adenocarcinoma, Amer. J. Surg., 121: 746–748, 1971.
Sato, T., Watanabe, K., Saitoh, Y., Koyama, K. and Suda, Y.: Selective arteriography for gallbladder diseases. Evaluation with reference to carcinoma of the gallbladder, Arch. Surg., 99: 598–605, 1969.
Savic, B., Schulz, D. and Raschke, E.: Die carcinoma des extrahepatischen biliären Systems. Mit einem Vorschlag zur Klassifizierung nach dem TNM System. Langenbeck Arch. Klin. Chir., 331: 23–37, 1972.
Solan, M. J. and Jackson, B. T.: Carcinoma of the gallbladder, A clinical appraisal andreview of 57 cases, Brit. J. Surg., 58: 593–597, 1971.
Sprayregen, S. and Messinger, N.: Carcinoma of the gallbladder: diagnosis and evaluation of regional spread by angiography, Amer. J. Roentgen, 116: 382–392, 1972.
Sugahara, K., Ohno, H., Kashii, A., Manaka, J., Shirakusa, T. and Okasaki, I.: Clinics of gallbladder cancer-its classification and surgical treatment, Geka (Surgery), 33: 1239–1245, 1971 (in Japanese).
Van Slyck, E. J. and Schuman, B. M.: Lymphocytic lymphosarcoma of the gallbladder, Cancer, 30: 810–816, 1972.
Warren, K. W., Hardy, K. J. and O'Ronke, M. G. E.: Primary neoplasia of the gallbladder, Surg. Gynec. Obstet., 126: 1036–1040, 1968.
Yasuma, T. and Yanaka, M.: Primary sarcoma of the gallbladder. Report of three cases, Acta Path. Jap., 21-2857304, 1971.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nakayama, F., Fujino, R., Iwamoto, T. et al. Early diagnosis of gallbladder malignancy. The Japanese Journal of Surgery 4, 96–103 (1974). https://doi.org/10.1007/BF02469038
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02469038