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The interaction of Insulin-like Growth Factors (IGFs) with Insulin-like Growth Factor Binding Proteins (IGFBPs): a review

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Abstract

The interactions between insulin-like growth factor bindingproteins (IGFBPs) and insulin-like growth factors (IGFs)are important in regulating the availability of IGFs to thetype 1 IGF receptor (IGF1R) but there is still a lack ofinformation regarding the mechanism of IGF binding byIGFBPs. While many studies have defined general regions ofthe IGFBPs that interact with IGFs, only recently havespecific IGF binding residues been described. This reviewwill outline the structural evidence describing residues ofboth the IGFBPs and IGFs involved in the IGFBP-IGFinteraction.

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References

  1. Boisclair, Y.R., Rhoads, R.P., Ueki, I., Wang, J. and Ooi, G.T.J., Endocrinology, 170 (2001) 63.

    Google Scholar 

  2. Baxter, R.C., Am. J. Physiol. Endocrinol. Metab., 278 (2000) E967.

    Google Scholar 

  3. Hwa, V., Oh, Y. and Rosenfeld, R.G., Endocr. Rev., 20 (1999) 761.

    Google Scholar 

  4. Baserga, R., Resnicoff, M. and Dews, M., Endocrine, 7 (1997) 99.

    Google Scholar 

  5. Sepp-Lorenzino, L., Breast Cancer Res. Treat., 47 (1998) 235.

    Google Scholar 

  6. Rechler, M.M., Vitam. Horm., 47 (1993) 1.

    Google Scholar 

  7. Baxter, R.C., Horm. Res., 42 (1994) 140.

    Google Scholar 

  8. Jones, J.I. and Clemmons, D.R., Endocr. Rev. 16 (1995) 3.

    Google Scholar 

  9. Forbes, B.E., Turner, D., Hodge, S.J., McNeil, K. A., Forsberg, G. and Wallace, J.C., J. Biol. Chem., 273 (1998) 4647.

    Google Scholar 

  10. Standker, L., Braulke, T., Mark, S., Mostafavi, H., Meyer, M., Honing, S., Gimenez-Gallego, G. and Forssmann, W., Biochemistry, 39 (2000) 5082.

    Google Scholar 

  11. Neumann, G.M., Marinaro, J.A. and Bach, L.A., Biochemistry, 37 (1998) 6572–6585.

    Google Scholar 

  12. Neumann, G.M. and Bach, L.A., J. Biol. Chem., 274 (1999) 14587.

    Google Scholar 

  13. Hashimoto, R., Ono, M., Fujiwara, H., Higashihashi, N., Yoshida, M., Enjoh Kimura, T. and Sakano, K.J., Biol. Chem., 272 (1997) 27936.

    Google Scholar 

  14. Kalus, W., Zweckstetter, M., Renner, C., Sanchez, Y., Georgescu, J., Grol, M., Demuth, D., Schumacher, R., Dony, C., Lang, K. and Holak, T.A., EMBO J., 17 (1998) 6558.

    Google Scholar 

  15. Chelius, D., Baldwin, M.A., Lu, X. and Spencer, E.M., J. Endocrinol., 168 (2001) 283.

    Google Scholar 

  16. Clemmons, D.R., Endocr. Rev., 22 (2001) 800.

    Google Scholar 

  17. Żeslawski, W., Beisel, H. G., Kamionka, M., Kalus, W., Engh, R.A., Huber, R., Lang, K. and Holak, T.A., EMBO J., 20 (2001) 3638.

    Google Scholar 

  18. Landale, E.C., Strong, D.D., Mohan, S. and Baylink, D.J., Growth Factors, 12 (1995) 245.

    Google Scholar 

  19. Cooke, R.M., Harvey, T.S. and Campbell, I.D., Biochemistry, 30 (1991) 5484.

    Google Scholar 

  20. Sato, A., Nishimura, S., Ohkubo, T., Kyogoku, Y., Koyama, S., Kobayashi, M., Yasuda, T. and Kobayashi, Y., J. Biochem., 111 (1992) 520.

    Google Scholar 

  21. Laajoki, L.G., Francis, G.L., Wallace, J.C., Carver, J.A. and Keniry, M.A., J. Biol. Chem., 275 (2000) 10009.

    Google Scholar 

  22. Renner, C. and Holak, T., Eur. J. Biochem., 268 (2001) 1058.

    Google Scholar 

  23. Bayne, M.L., Applebaum, J., Chicchi, G.G., Hayes, N.S., Green, B.G. and Cascieri, M.A., J. Biol. Chem. 263 (1988) 6233.

    Google Scholar 

  24. Clemmons, D.R., Dehoff, M.L., Busby, W.H., Bayne, M.L. and Cascieri, M.A., Endocrinology, 131 (1992) 890.

    Google Scholar 

  25. Oh, Y., Mueller, H.L., Lee, D.Y., Fielder, P.J. and Rosenfeld, R.G., Endocrinology, 132 (1993) 1337.

    Google Scholar 

  26. Carrick, F.E., Forbes, B.E. and Wallace, J.C., J. Biol. Chem., 276 (2001) 27120.

    Google Scholar 

  27. Galanis, M., Firth, S.M., Bond, J., Nathanielsz, A., Kortt, A.A., Hudson, P.J. and Baxter, R.C.J., Endocrinol., 169 (2001) 123.

    Google Scholar 

  28. Ho, P.J. and Baxter, R.C., Endocrinology, 138 (1997) 3811.

    Google Scholar 

  29. Chernausek, S.D., Smith, C.E., Duffin, K.L., Busby, W.H., Wright, G. and Clemmons, D.R., J. Biol. Chem., 270 (1995) 11377.

    Google Scholar 

  30. Andress, D.L., Loop, S.M., Zapf, J. and Kiefer, M.C., Biochem. Biophys. Res. Commun., 195 (1993) 25.

    Google Scholar 

  31. Durham, S.K., Riggs, B.L., Harris, S.A. and Conover, C.A., Endocrinology, 136 (1995) 1374.

    Google Scholar 

  32. Conover, C.A., Durham, S.K., Zapf, J., Masiarz, F.R. and Kiefer, M.C., J. Biol. Chem., 270 (1995) 4395.

    Google Scholar 

  33. Spencer, E.M. and Chan, K., Prog. Growth Factor Res., 6 (1995) 209.

    Google Scholar 

  34. Zapf, J., Born, W., Chang, J.Y., James, P., Froesch, E.R. and Fischer, J.A., Biochem. Biophys. Res. Commun., 156 (1988) 1187.

    Google Scholar 

  35. Wang, J.F., Hampton, B., Mehlman, T., Burgess, W.H. and Rechler, M.M., Biochem. Biophys. Res. Comm., 157 (1988) 718.

    Google Scholar 

  36. Sommer, A., Maack, C.A., Spratt, S.K., Mascarenhas, D., Tressel, T.J., Rholdes, E.T., Lee, R., Roumas, M., Tatsuno, G.P., Flynn, J.A., Gerber, N., Taylor, J., Cundy, H., Nannet, L., Hunt, T.K., Spencer, E.M., in Spencer E.M. (ed.) Molecular genetics and actions of recombinant insulin-like growth factor binding protein-3. Modern Concepts of Insulin-like Growth Factors. Elsevier, New York, 1991, pp. 715.

    Google Scholar 

  37. Horney, M.J., Evangelista, C.A. and Rosenzweig, S.A., J. Biol. Chem., 276 (2001) 2880.

    Google Scholar 

  38. Hobba, G.D., Forbes, B.E., Parkinson, E.J., Francis, G.L. and Wallace, J.C., J. Biol. Chem., 271 (1996) 30529.

    Google Scholar 

  39. Hobba, G.D., Lothgren, A., Holmberg, E., Forbes, B.E., Francis, G.L. and Wallace, J.C., J. Biol. Chem., 273 (1998) 19691.

    Google Scholar 

  40. Imai, Y., Moralez, A., Andag, U., Clarke, J.B., Busby, W.H., Jr. and Clemmons, D.R., J. Biol. Chem., 275 (2000) 18188.

    Google Scholar 

  41. Clemmons, D.R., Cascieri, M.A., Camacho-Hubner, C., McCusker, R.H. and Bayne, M.L., J. Biol. Chem., 265 (1990) 12210.

    Google Scholar 

  42. Qin, X., Strong, D.D., Baylink, D.J. and Mohan, S.J., Biol. Chem., 273 (1998) 23509.

    Google Scholar 

  43. Bramani, S., Song, H., Beattie, J., Tonner, E., Flint, D.J. and Allan, G.J., J. Mol. Endocrinol., 23 (1999) 117.

    Google Scholar 

  44. Firth, S.M., Ganeshprasad, U. and Baxter, R.C.J., Biol. Chem., 273 (1998) 2631.

    Google Scholar 

  45. Bagley, C.J., May, B.L., Szabo, L., McNamara, P.J., Ross, M., Francis, G.L., Ballard, F.J. and Wallace, J.C., Biochem. J., 259 (1989) 665.

    Google Scholar 

  46. Francis, G.L., Aplin, S.E., Milner, S.J., McNeil, K.A., Ballard, F.J. and Wallace, J.C., Biochem. J., 293 (1993) 713.

    Google Scholar 

  47. Sara, V.R., Carlsson-Skwirut, C., Andersson, C., Hall, E., Sjogren, B., Holmgren, A. and Jornvall, H., Proc. Natl. Acad. Sci. U.S.A., 83 (1986) 4904.

    Google Scholar 

  48. Vajdos, F.F., Ultsch, M., Schaffer, M.L., Deshayes, K.D., Liu, J., Skelton, N.J. and de Vos, A.M., Biochemistry, 40 (2001) 11022.

    Google Scholar 

  49. Torres, A.M., Forbes, B.E., Aplin, S.E., Wallace, J.C., Francis, G.L. and Norton, R.S.J., Mol. Biol., 248 (1995) 385.

    Google Scholar 

  50. Bach, L.A., Hsieh, S., Sakano, K.I., Fujiwara, H., Perdue, J.F. and Rechler, M.M., J. Biol. Chem., 268 (1993) 9246.

    Google Scholar 

  51. Magee, B.A., Shooter, G.K., Wallace, J.C. and Francis, G.L., Biochemistry, 38 (1999) 15863.

    Google Scholar 

  52. Dubaquie, Y. and Lowman, H.B., Biochemistry, 38 (1999) 6386.

    Google Scholar 

  53. Ehring, H., Anal. Biochem., 267 (1999) 252.

    Google Scholar 

  54. Jansson, M., Andersson, G., Uhlen, M., Nilsson, B. and Kordel, J., J. Biol. Chem., 273 (1998) 24701.

    Google Scholar 

  55. Cascieri, M.A., Chicchi, G.G., Applebaum, J., Green, B.G., Hayes, N.S. and Bayne, M.L., J. Biol. Chem., 264 (1989) 2199.

    Google Scholar 

  56. Loddick, S.A., Liu, X.J., Lu, Z.X., Liu, C., Behan, D.P., Chalmers, D.C., Foster, A.C., Vale, W.W., Ling, N. and De Souza, E.B., Proc. Natl. Acad. Sci. U.S.A., 95 (1998) 1894.

    Google Scholar 

  57. Lowman, H.B., Chen, Y.M., Skelton, N.J., Mortensen, D.L., Tomlinson, E.E., Sadick, M.D., Robinson, I. C. and Clark, R.G., Biochemistry, 37 (1998) 8870.

    Google Scholar 

  58. Liu, X.J., Xie, Q., Zhu, Y.F., Chen, C. and Ling, N., J. Biol. Chem., 276 (2001) 32419.

    Google Scholar 

  59. Skelton, N.J., Chen, Y.M., Dubree, N., Quan, C., Jackson, D.Y., Cochran, A., Zobel, K., Deshayes, K., Baca, M., Pisabarro, M.T. and Lowman, H.B., Biochemistry, 40 (2001) 8487.

    Google Scholar 

  60. Koradi, R., Billeter, M. and Wuthrich, K., J. Mol. Graph., 14 (1996) 51.

    Google Scholar 

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Authors and Affiliations

  1. CRC for Tissue Growth and Repair, Department of Molecular Biosciences, Adelaide University, South Australia, Australia, 5005

    Francine E. Carrick, John C. Wallace & Briony E. Forbes

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  1. Francine E. Carrick
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Carrick, F.E., Wallace, J.C. & Forbes, B.E. The interaction of Insulin-like Growth Factors (IGFs) with Insulin-like Growth Factor Binding Proteins (IGFBPs): a review. Letters in Peptide Science 8, 147–153 (2001). https://doi.org/10.1023/A:1016253819108

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