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Effect of melittin on the contractility of rat papillary muscle

  • Physiology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Melittin, a phospholipase A2 activator, induces two-phase changes in the contractility of isolated rat papillary muscle. The first phase is characterized by an increase in the force of muscle contraction during the first 5–15 min of perfusion, the increase being the greatest at 0.4 μg/ml melittin. This phase is abolished by 10 μM indomethacin. In the second phase, dose-dependent inhibition of muscle contraction reaches the maximum after 30–45 min of perfusion and is abolished by the lipoxygenase inhibitor nordihydroguaiaretic acid (10 μM).

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Authors and Affiliations

  1. Department of Experimental Cardiology, Institute of Physiology, Ukrainian Academy of Sciences, Kiev

    V. M. Brovkovich & A. A. Moibenko

Authors
  1. V. M. Brovkovich
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  2. A. A. Moibenko
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 7, pp. 25–27, July, 1997

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Brovkovich, V.M., Moibenko, A.A. Effect of melittin on the contractility of rat papillary muscle. Bull Exp Biol Med 124, 642–644 (1997). https://doi.org/10.1007/BF02445049

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  • DOI: https://doi.org/10.1007/BF02445049

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