Abstract
The submucosal connective tissue of the jejunum has been shown to be suitable for use as a vascular graft in preliminary dog studies. To partially characterize the mechanical properties of this new graft material, longitudinal stress (σ)-strain (ε)-data were obtained on 13 specimens of canine jejunum, stripped of its mucosal and external smooth-muscle layers. The ratio of stress to strain is the modulus of elasticity (E). It was found that the stress σ-strain ε-data fitted the expressionγ=K∈ α very well. For a typical specimenγ=2.69×106∈2.33. The modulus of elasticity (E=γ 1-1/α K 1/α) was found to increase with increasing stress, ranging from about 2,000 to 9,000 mmHg. For the average specimenE=573γ 0.57, where σ is in mmHg, (1 mmHg=133.3 Pascals).
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References
Badylak, S.F.; Lantz, G.; Coffey, A. Small intestine as an autogenous vascular graft. J. Surg. Res. 47:74–80; 1989.
Bergel, D.H. The static elastic properties of the arterial wall. J. Physiol. (Lond.) 156:445–457; 1961.
Bergel, D.H. The dynamic elastic properties of the arterial wall. J. Physiol. (Lond.) 156:458–469; 1961.
Blakemore, A.H.; Voorhees, Jr., A.B. The use of tubes constructuted of vinyon-N cloth in bridging arterial defects: Experimental and clinical. Ann. Surg. 140:324; 1954.
Callow, A.D. History of vascular graft development, vascular graft update: Safety and performance. ASTM STP 698. In: Kambic, H.E.; Kantrowitz, A.; Sung, P.; eds. Philadelphia; ASTM; 1986: pp. 11–16.
Gow, B.S.; Taylor, M.G. Measurement of viscoelastic properties of arteries in the living dog. Circ. Res. 23:111–122; 1968
Hughes, D.J.; Fearnot, N.E.; Babbs, C.F.; Bourland, J.D.; Geddes, L.A. Continuous measurement of aortic radius change in vivo with an intra-aortic ultrasonic catheter. Med. Biol. Eng. Comput. 23(3); 197–202; 1985.
Kinley, C.E.; Paasche, P.E.; MacDonald, A.S.; Marble, A.E.; Gozna, E.R. Stress at vascular anastomosis in relation to host artery. Surgery 75:28; 1974.
Lantz, G.; Badylak, S.F.; Coffey, A. Small intestinal submucosa as a small diameter arterial autograft in the dog. J. Invest. Surg. 3:217–227; 1990.
Lyman, D.J.; Stewart, S.F.C. Essential physical characteristics of vascular grafts, modern vascular grafts. Philadelphia: Saunders; 1973: pp. 115–132.
Nickerson, J.L.; Drozic, M. Young's modulus and breaking strength of body tissues. US Aerospace Medical Research Laboratories, No. AMRL-TDR-64-23 Technical Report; March 1964.
Posey, J.A.; Geddes, L.A. Measurement of the modulus of elasticity of the arterial wall. Cardiovasc. Res. Ctr. Bull. 111(4):83–103; 1973.
Seifert, K.B.; Albo, Jr., D.; Knowlton, H.; Lyman, D.J. Effect of elasticity of prosthetic wall on patency of small diameter arterial prostheses. Surg. Forum 30:206; 1979.
Sumner, D.S.; Hokanson, D.E.; Strandness, D.E. Arterial walls before and after endarterectomy. Stress-strain characteristics and collagen-elastin content. Arch. Surg. 99:606–611; 1969.
Sumner, D.S.; Hokanson, D.E.; Strandness, D.E. Stress-strain characteristics and collagen-elastin content of abdominal aortic aneurysms. Surg. Gynecol. Obstet. 130:459–466; 1970.
Voorhees, Jr., A.B.; Jaretzke, III, A.L.; Blakemore, A.H. The use of tubes constructed from Vinyon-“N” cloth in bridging arterial defects. Ann. Surg. 135:332; 1952.
Wesolowski, S.A.; Fries, C.C.; Domingo, R.T.; Liebig, W.J.; Sawyer, P.N. The compound prosthetic vascular graft: A pathologic survey. Surgery 53:19; 1963.
Wesolowski, S.A.; Fries, C.C.; Karlson, K.E.; DeBakey, M.E.; Sawyer, P.N. Porosity: Primary determinant of ultimate fate of synthetic vascular grafts. Surgery 50:91; 1961.
Wesolowski, S.A.; Fries, C.C.; Sawyer, P.N. Some desirable physical characteristics of prosthetic vascular grafts. In: Sawyer, P.N., ed. Biophysical mechanisms in vascular homeostasis and intravascular thrombosis. New York: Appleton-Century-Crofts; 1965: p. 331.
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Herbert, S.T., Badylak, S.F., Geddes, L.A. et al. Elastic modulus of prepared canine jejunum, a new vascular graft material. Ann Biomed Eng 21, 727–733 (1993). https://doi.org/10.1007/BF02368651
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DOI: https://doi.org/10.1007/BF02368651