Abstract
Ultrastructural examination of white blood cells of 8 patients with neuronal ceroid lipofuscinosis showed the characteristic cytosomes, i.e. curvilinear bodies, fingerprint profiles, osmiophilic bodies, as seen in nerve cells. The reliability of this simple technique in the diagnostic work-up of this progressive neurodegenerative disorder is emphasized.
Sommario
Vengono presentati i risultati dell'indagine ultrastrutturale dei linfociti circolanti in 8 pazienti affetti da Ceroido-Lipofuscinosi Neuronale. Nel citoplasma delle cellule ematiche sono stati osservati i medesimi citosomi (corpi curvilinei, processi ad impronte digitate, corpi osmiofili), che si riscontrano nei neuroni. Vengono sottolineati i vantaggi di questa semplice metodica nell'iter diagnostico di questa encefalopatia degenerativa a carattere progressivo.
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Simonati, A., Rizzuto, N. Blood lymphocytes in neuronal ceroid lipofuscinosis. Ital J Neuro Sci 9, 249–253 (1988). https://doi.org/10.1007/BF02334048
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DOI: https://doi.org/10.1007/BF02334048