Summary
The role of endogenous prostaglandins in the modulation of lower oesophageal sphincter (LES) function has been assessed by giving three structurally unrelated cyclooxygenase inhibitors and monitoring their acute effects on LES tonus and platelet thromboxane (TX) B2 production in 20 healthy volunteers.
In a double-blind, placebo-controlled, cross-over study, IV injection of soluble salts of acetylsalicylic acid and indomethacin elicited a transient increase in LES tonus of approximately 50% over baseline. A similar pattern was observed after the rectal administration of indomethacin.
In contrast, indoprofen had no measurable effect on LES tones, despite comparable inhibition of platelet cyclooxygenase activity. This may have been due to the markedly different tissue distribution of the drug.
The results suggest that endogenous prostaglandins physiologically exert an inhibitory influence on LES function.
References
Brown F, Beck B, Fletcher J, Castel D, Eastwood G (1977) Evidence suggesting prostaglandins mediate lower oesophageal sphincter (LES) incompetence associated with inflammation. Gastroenterology 72: 1033–1038
Castrucci G, Alimandi L, Gattavilla N, Caracciolo F, Salgarello G (1984) Esofagomanometria: aspetti metodologici ed applicazioni clinico-sperimentali. Chir Pat Sper 32: 195–213
Code CF, Schlegel JF (1958) The pressure profile of the gastrooesophageal sphincter in man: animproved method of detection. Proc Staff Meet Mayo Clinic 33: 406–416
Dilawari JB, Newman A, Poleo J, Misiewicz JJ (1975) Response of the human cardiac sphincter to circulating prostaglandins E2 and F2 and to antiinflammatory drugs. Gut 16: 137–143
Mc Callum RW, Ippoliti AF, Studervant RAL (1975) Effect of oral 16,16 dimetyl prostaglandin E2(PGE2) on the lower oesophageal sphincter in man. Gastroenterology 68: 949–956
Mayeux PR, Kadowitz PJ, Mc Namara DB (1982) Differential effects of ibuprofen, indomethacin, and meclofenamate on prostaglandin endoperoxide H2 metabolism. Molec Cell Biochem 87: 41–46
Mukhopadhyay A, Rattan S, Goyal RK (1975) Effect of prostaglandin E2 on oesophageal motility in man. J Appl Physiol 39: 479–481
Nishikawa T, Tomori Y, Yamashita S, Shimizu S (1989) Different modes of inhibition of rat gastric mucosal 6-keto-PGF1 alpha production by indomethacin, aspirin and aminopyrine. Jpn J Pharmacol 49: 483–489
Patrono C, Ciabattoni G, Pugliese F, Pierucci A, Blai JA, FitzGerald GA (1986) Estimated rate of thromboxane secretion into the circulation of normal humans. J Clin Invest 77: 590–594
Patrono C, Ciabattoni G, Pinca E, Pugliese F, Castrucci G, De Salvo A, Satta MA, Peskar BA (1980) Low-dose aspirin and inhibition of thromboxane BZ production in healthy subjects. Thromb Res 17: 317–321
Rosati F, Gattavilla N, Salgarello G (1981) A simple and cheap system of perfusion for manometry. Acta Medica Rom 19: 296–300
Sallustio BC, Meffin PJ, Knights KM (1988) The stereospecific incorporation of fenopren into rat hepatocyte and adipocyte triacylglycerols. Biochem Pharmacol 37: 1919–1923
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Cagossi, M., Salgarello, M., Patrignani, P. et al. Effects of various prostaglandin synthesis inhibitors on the tone of the lower oesophageal sphincter in man. Eur J Clin Pharmacol 43, 303–305 (1992). https://doi.org/10.1007/BF02333028
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DOI: https://doi.org/10.1007/BF02333028