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Molecular analysis of medulloblastomas occurring simultaneously in monozygotic twins

  • Hematology/Oncology
  • Published:
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Abstract

We report male monocygotic twins with concordant desmoplastic medulloblastoma diagnosed at the age of 20 months. Both tumours were completely removed. As chromosomal loci 17p13 and 9831 are frequently altered in medulloblastoma these regions were analysed in both tumours in detail using restriction fragment length polymorphism and microsatellite analysis. No common aberration was found. The c-myc gene on chromosome 8g21 was not amplified.

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Abbreviations

APC :

adenomatous polyposis coli

LOH :

loss of heterozygosity

NBCCS :

nevoid basal cell carcinoma syndrome

PBL :

peripheral blood lymphocyte

PCR :

polymerase chain reaction

PNET :

primitive neuro-ectodermal tumour

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Authors and Affiliations

  1. Department of Paediatrics, University of Würzburg, Josef-Scheider-Strasse 2, D-97080, Wurzburg, Germany

    W. Scheurlen & J. Kühl

  2. Department of Paediatric Neurosurgery, University of Würzburg, D-97080, Wurzburg, Germany

    N. Sörensen

  3. Department of Neuropathology, University of Würzburg, D-97080, Würzburg, Germany

    W. Roggendorf

Authors
  1. W. Scheurlen
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  2. N. Sörensen
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  3. W. Roggendorf
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  4. J. Kühl
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Scheurlen, W., Sörensen, N., Roggendorf, W. et al. Molecular analysis of medulloblastomas occurring simultaneously in monozygotic twins. Eur J Pediatr 155, 880–884 (1996). https://doi.org/10.1007/BF02282838

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  • DOI: https://doi.org/10.1007/BF02282838

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