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Stability of corticosteroids under anaerobic conditions

II. 17-deoxy-21-dehydroprednisolone

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Abstract

One of the identified decomposition products formed during the anaerobic decomposition of prednisolone, is 17-deoxy-21-dehydroprednisolone. This product can only be detected when the decomposition of prednisolone takes place at about pH = 6 or lower pH values.

The Chromatographic properties, the isolation and the structure elucidation of 17-deoxy-21-dehydroprednisolone are given.

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References

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Authors and Affiliations

  1. Department of Analytical Pharmacy, Faculty of Pharmacy, State University of Utrecht, Catharijnesingel 60, 3511, GH Utrecht, The Netherlands

    D. Dekker

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  1. D. Dekker
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Part 1, seeDekker, D. (1979)Pharm. Weekblad Sci. Ed. 1, 112.

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Dekker, D. Stability of corticosteroids under anaerobic conditions. Pharmaceutisch Weekblad Scientific Edition 2, 266–270 (1980). https://doi.org/10.1007/BF02272991

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  • DOI: https://doi.org/10.1007/BF02272991

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