Abstract
The structure of 4(dimethylamino)-1, 4, 4a, 5, 5a, 6, 11, 12a-octahydro-3, 5, 10, 12, 12a-pentahydroxy-6-methylene-1, 11-dioxo-2-naphthacenecarboxamide hydrobromide salt was determined by an X-ray analysis. One methacycline cation and one bromide anion were found in the asymmetric unit of an orthorhombic cell, space group P212121,a 9.580(1),b 12.147(2),c 18.735(3) å,V2180.0(5) å3, Z4,D c 1.59 g cm−3, Μ(MoKα) 19.15 cm−1. The structure was solved and refined toR(F) 0.062 andR w(F) 0.064 by a full matrix least-squares procedure. The conformation of the methacycline cation is found to be similar to that reported for 6-demethyl-7-chlorotetracycline hydrochloride trihydrate.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Sheldrick, G. M. SHELX, a Crystallographic Calculation Program, University of Cambridge, 1976.
International Tables for X-ray Crystallography, Kynoch Press: Birmingham, England, 1974; Vol. IV.
Johnson, C. K. ORTEP-II, Report ORNL-5138, Oak Ridge National Laboratory, Tennessee, 1976.
Mooibroek, S.; Wasylishen, R. E.Can. J. Chem. 1987,65, 357–362.
Palenik, G. J.; Mathew, M.J. Am. Chem. Soc. 1978,100, 4464–4469.
Cremer, D.; Pople, J. A.J. Am. Chem. Soc. 1975,97, 1354–1358.
Allen, F. H.; Kennard, O.; Taylor, R.Acc. Chem. Res. 1983,16, 146–153.
Palenik, G. J.; Mathew, M.; Restivo, R.J. Am. Chem. Soc. 1978,100, 4458–4464.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Carrondo, M.A.A.F.d.C.T., Matias, P.M., Heggie, W. et al. Molecular structure of 6-methyleneoxytetracycline hydrobromide. Struct Chem 5, 73–77 (1994). https://doi.org/10.1007/BF02265348
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02265348