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Prevention of DNA 5-methylcytosine reutilization in human cells

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Somatic Cell and Molecular Genetics

Abstract

DNA methylation is an important process contributing to transcriptional regulation in animal and plant cells. The well known reutilization of DNA nucleotide bases indicated that DNA degradation occurs in many cells and tissues. On the other hand, the reutilization of 5-methyl-2′-deoxycytidine monophosphate in the DNA synthesis would have deleterious effects on gene regulation. Recent molecular insights into the exclusion of exogenous 5-methylcytosine from DNA are the subject of this review.

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Authors and Affiliations

  1. Laboratory of Molecular Hematology, Department of Clinical Chemistry, Tampere University Hospital, P.O. Box 2000, SF-33521, Tampere, Finland

    Juhani A. Vilpo & Leena M. Vilpo

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  1. Juhani A. Vilpo
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  2. Leena M. Vilpo
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Vilpo, J.A., Vilpo, L.M. Prevention of DNA 5-methylcytosine reutilization in human cells. Somat Cell Mol Genet 21, 285–288 (1995). https://doi.org/10.1007/BF02255783

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  • DOI: https://doi.org/10.1007/BF02255783

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