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Comparative relationship between serum gastrin concentration and gastric acid output

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Abstract

Gastric hydrochloric acid output and serum gastrin concentrations were compared to determine whether there was any correlation between circulating serum gastrin levels and acid output in the fasting, interdigestive state of the dog, miniature pig and monkey (Macaca mulatta). No correlation was seen in any species except in the anesthetized, vagotomized dog. In the monkey and miniature pig, interdigestive secretion is predominantly controlled by direct vagal stimulation of the parietal cell. Conversely, in the anesthetized, vagotomized dog, acid secretion may be primarily under gastrin control.

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Authors and Affiliations

  1. From the Department of Physiology and Medicine, University of Pennsylvania Schools of Medicine and Veterinary Medicine and Veterans Administration Hospital, Philadelphia, Pa

    G. Lanciault PhD, A. Merritt MS, DVM, E. Rosato MD, C. Bonoma BS & F. P. Brooks MD, DSc

Authors
  1. G. Lanciault PhD
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  2. A. Merritt MS, DVM
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  3. E. Rosato MD
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  4. C. Bonoma BS
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  5. F. P. Brooks MD, DSc
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Lanciault, G., Merritt, A., Rosato, E. et al. Comparative relationship between serum gastrin concentration and gastric acid output. Digest Dis Sci 17, 523–526 (1972). https://doi.org/10.1007/BF02231208

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  • DOI: https://doi.org/10.1007/BF02231208

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