Abstract
Pulmonary function testing was performed in calves affected with bronchopneumonia. In these calves respiratory rate, viscous work per litre air and per minute, intrapleural pressure difference, mean inspiratory and expiratory flow rate and ventilation per minute were significantly increased. Total resistance of the lung was just not significantly increased. Dynamic compliance and tidal volume were significantly reduced.
The main effect of clenbuterol was a significant increase in dynamic compliance. The reduction in the total resistance of the lung was just not significant. These results indicate that clenbuterol can antagonise, at least partly, the alterations caused by bronchopneumonia.
Similar content being viewed by others
References
Behrens, H.J., 1983. VentipulminR-Granulat bei der Behandlung der Rindergrippe. Tierärztl. Umschau, 38: 628–632.
Brown, R., 1969. Physiological effects of experimental airway obstruction with beads. J. Appl. Physiol., 27:328–335.
Fenner, A., 1982. Atemfrequens, Atemminutenvolumen und Atemzugvolumen bei klinisch gesunden und bei an Bronchopneumonie erkrankten Mastrindern unter Beruchsichtigung der Wirkung von Clenbuterol. München, Tierärtzliche Hochschule, Diss.
Kiorpes, A.L., Bisgard, G.E., Manohar, M. and Hernandez, A., 1978. Pathophysiological studies of Infectious Bovine Rhinotracheitis in the Holstein-Friesian calf. Am. J. Vet. Res. 39: 779.
Lekeux, P. 1984. Physiological studies of the pulmonary function in unsedated Friesian cattle. Thesis, Fac. Méd. Vet. Liège, Rue des Vétérinaires, Brussels.
Nuytten, J., Muylle, E. and Oyaert, W. 1985. Pulmonary haemodynamics in healthy calves and in calves suffering from respiratory disorders. Zbl. Vet. Med. A., 32, 81–85.
Nuytten, J., Muylle, E., Oyaert, W. and Van Den Hende, C., 1986. The influence of clenbuterol on prostaglandin F2α-induced dyspnoea in calves. Vet. Res. Commun., 10: 453–461.
Otis, A.B., 1956, Mechanical factors in distribution of pulmonary ventilation. J. Appl. Physiol. 8: 421–443.
Roudebush, P., 1982. Lung Sounds. J.A.V.M.A. 181: 122–127.
Slocombe, R.F. and Robinson, N.E., 1981. Histamine H1, H2 receptor effects on mechanics of ventilation and gas exchange in neonatal-calves. Am. J. Vet. Res. 42, 764–769.
Schreurs, A.J.M. and Nijkamp, F.P., 1984.Hemophilus influenzae and the β-adrenergic system: a review. Vet. Res. Commun., 8: 1–14.
Verschooten, F., Oyaert, W. and Drubbel, R., 1974. Radiographic diagnosis of lung diseases in cattle. J. Am. Vet. Radiolog. Soc. 15: 49–59.
Von Radicke, R., 1984. Ventipulmin in der Rinderpraxis. Der praktische Tierärzt. 2:136–137.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nuytten, J., Muylle, E., Oyaert, W. et al. The effect of clenbuterol on lung function parameters in calves suffering from bronchopneumonia. Vet Res Commun 10, 463–467 (1986). https://doi.org/10.1007/BF02214009
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02214009