Summary
Cysteine proteases of the papain superfamily are usually considered to possess a relatively broad substrate specificity. However, despite a number of similarities between cysteine proteases, unique and/or restricted preferences for substrates have been served in a few cases and differences do exist that can form the basis for the design of more specific inhibitors. Recent crystallographic measurements coupled to mutational analysis have allowed the molecular basis behind several of these specificity determinants to be uncovered.
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Storer, A.C., Ménard, R. Recent insights into cysteine protease specificity: Lessons for drug design. Perspectives in Drug Discovery and Design 6, 33–46 (1996). https://doi.org/10.1007/BF02174044
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DOI: https://doi.org/10.1007/BF02174044