Die Wirkung von Patulin auf das myelound lymphopoetische System der Maus

Summary

Patulin was examined in regard to its effect upon the different white blood cells in white mice. There is a very noticeable influence on the lymphocyte count in the circulating blood, which was reduced by daily injections of patulin 0.1 mg i. p. from 8–15,000 to 1–3,000, while the granulocytes were scarcely affected. After the injections were stopped, the lymphocyte count increased again, and sometimes an increase of the granulocytes has been noticed. Often mice died from abscesses in different organs. Patulin seems to have an inhibitory effect on lymphatic tissues, like carbamates and nitrogen mustard. Whether there is a growth inhibitory effect on tumours is now an object of study.