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Histamine release from human adenoidal and mesenteric mast cells induced by bacterial antigens

  • Mast Cell Heterogeneity and Subtypes
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Abstract

The histamine-releasing capability ofStaphylococcus aureus antigens was examined in human adenoidal and mesenteric mast cells obtained by enzymic dispersion of tissues from non-allergic patients. Both populations of mast cells released histamine after challenge with bacterial protein in concentrations between 5–500 μg/ml. The release was dependent on the dose, temperature and metabolic energy. The maximum release was observed at 15 min after challenge. The present results suggest thatStaphylococcus aureus antigens release histamine from human adenoidal and mesenteric mast cells via a non-cytotoxic, active secretory process.

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Authors and Affiliations

  1. Department of Biogenic Amines, Polish Academy of Sciences, Narutowicza 60, 90-136, Łódź, Poland

    E. Brzezińska-Błaszczyk, M. Czuwaj & J. Wyczółkowska

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  1. E. Brzezińska-Błaszczyk
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  2. M. Czuwaj
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  3. J. Wyczółkowska
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Brzezińska-Błaszczyk, E., Czuwaj, M. & Wyczółkowska, J. Histamine release from human adenoidal and mesenteric mast cells induced by bacterial antigens. Agents and Actions 23, 230–232 (1988). https://doi.org/10.1007/BF02142549

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