Skip to main content
SpringerLink
Log in

Acidic metabolite of prednisolone

  • Published:
Experientia Aims and scope Submit manuscript

Summary

The metabolic fate of the 17β-ketol side chain of (21-3H) prednisolone was studied with an enzyme preparation from male golden hamster liver. The acidic metabolite of prednisolone was identified by mass spectrometry as 11β, 17α,20ξ-trihydroxy-3-oxo-1,4-pregnadien-21-oic acid. The enzyme showed substrate specificity, depending on the nature of substituent on the steroid nucleus.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. C. M. Southcott, S. K. Gondoss, A. D. Barker, H. E. McIntosh and M. Darrach, Can. J. Biochem. Physiol.34, 146 (1956).

    Article  CAS  PubMed  Google Scholar 

  2. C. H. Gray and D. H. Shaw, J. Endocr.33, 33 (1965).

    Article  CAS  PubMed  Google Scholar 

  3. H. Bradlow, B. Zumoff, C. Monder, H. J. Lee and L. Hellman, J. clin. Endocr. Metab.37, 811 (1973).

    Article  CAS  PubMed  Google Scholar 

  4. A. C. Day and I. R. Senciall, J. Steroid Biochem.7, 167 (1976).

    Article  Google Scholar 

  5. H. J. Lee, K. O. Martin and C. Monder, Fed. Proc. USA34, 2516 (1975).

    Google Scholar 

  6. P. K. Willingham and C. Monder, Steroids22, 539 (1973).

    Article  CAS  PubMed  Google Scholar 

  7. H. J. Lee, R. Roboz and C. Monder, 23rd Conf. Mass Spec. PSA5 (1976).

Download references

Author information

Authors and Affiliations

  1. School of Pharmacy, Florida Agricultural and Mechanical University, 32307, Tallahassee, Florida, USA

    H. J. Lee

Authors
  1. H. J. Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This investigation was supported in part by USPHS Grant CA 2515.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lee, H.J. Acidic metabolite of prednisolone. Experientia 33, 253–254 (1977). https://doi.org/10.1007/BF02124095

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02124095

Keywords

Search

Navigation