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Jejunoileal transplantation

Effects on characteristics of canine jejunal motor activityin Vivo

  • Intestinal Disorders, Inflammatory Bowel Disease, Immunology, And Microbiology
  • Published:
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Abstract

This study was designed to determine if extrinsic innervation and intrinsic neural continuity with the duodenum (neuroenteric physiologic pathways disrupted during intestinal transplantation) modulate the characteristics of interdigestive motor activity in the canine small bowel. Five dogs served as neurally intact controls (group 1) and 10 dogs (group 2) underwent a model of jejunal autotransplantation involvingin situ neural isolation of the jejunoileum. Fasting duodenal and jejunal motor activity was recorded on-line to a microcomputer using closely spaced duodenal and jejunal manometry catheters. Characteristics of global motor patterns, the migrating motor complex (MMC), and local motor patterns, including individual contractions and grouped clustered contractions, were determined. Neural isolation of the jejunoileum disrupted coordination of duodenal and jejunal phase III activity, increased the variability of cycling of the MMC, decreased the period of the jejunal MMC, and increased motility indices in the neurally isolated jejunum. In contrast, single pressure waves and clustered contractions in the neurally isolated jejunum were not altered significantly in incidence or direction, distance, or velocity of spread.In situ neural isolation of the jejunoileum leads to temporal dissociation of the MMC between the transplanted segment (jejunum) and the duodenum but does not appear to alter markedly the characteristics of local contractile activity as measured by individual or grouped contractions. The occurrence of interdigestive jejunal motor patterns and the local organization of individual and grouped small intestinal contractions are not controlled by extrinsic innervation or intrinsic neural continuity with the duodenum.

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Author notes

  1. Kevin E. Behrns MD

    Present address: Department of Surgery, University of North Carolina at Chapel Hill, Campus Box 7210 Burnett-Womack Clinical Sciences Building, Chapel Hill, North Carolina, 27599-7210

Authors and Affiliations

  1. From the Department of Surgery, Gastroenterologic Research Unit, USA

    Kevin E. Behrns MD, Michael G. Sarr MD, Russell B. Hanson BA & Alan R. Zinsmeister PhD

  2. the Department of Health Science Research, Mayo Clinic and Mayo Foundation, Rochester, Minnesota

    Kevin E. Behrns MD, Michael G. Sarr MD, Russell B. Hanson BA & Alan R. Zinsmeister PhD

Authors
  1. Kevin E. Behrns MD
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  2. Michael G. Sarr MD
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  3. Russell B. Hanson BA
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  4. Alan R. Zinsmeister PhD
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Additional information

This work was supported by the USPHS (NIH grant DK39337) and the Mayo Foundation.

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Behrns, K.E., Sarr, M.G., Hanson, R.B. et al. Jejunoileal transplantation. Digest Dis Sci 41, 884–893 (1996). https://doi.org/10.1007/BF02091527

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  • DOI: https://doi.org/10.1007/BF02091527

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