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Gastric emptying of solids but not liquids is decreased in rats with chronic renal failure

  • Esophageal, Gastric, And Duodenal Disorders
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Abstract

Severe gastric complications occur in uremic patients, yet few studies have addressed the effect of chronic renal failure (RF) on gastric physiology. In the present study, we investigated: (1) the effect of RF on gastric emptying of liquids and solids in awake rats, (2) the motor function in the gastric corpus, and (3) the role of nitric oxide in any alterations in gastric motor function in uremic rats. RF was induced by partial kidney infarction. RF had no effect on gastric emptying of liquids but significantly inhibited gastric emptying of solids by 68%.N-Nitro-l-arginine, an inhibitor of nitric oxide (NO) synthesis, had no effect on the reduced gastric emptying of solids in RF rats. RF rats showed an altered pattern of gastric motility compared to sham-operated rats. These data suggest that RF induced an inhibition of gastric emptying of solids, but not liquids. However, NO does not seem to play a role in this inhibition.

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References

  1. Kang JY: The gastrointestinal tract in uremia. Dig Dis Sci 38:257–268, 1993

    Google Scholar 

  2. Wright RA, Clementi R, Watlen R: Gastric emptying in patients with CRF receiving hemodialysis. Arch Intern Med 144:495–496, 1984

    Google Scholar 

  3. Dumitrascu D-L, Barnert J, Kirschner T, Volert C, Bittinger M, Weinbeck M: Delayed gastric emptying in non-diabetic chronic renal failure (CRF): Evidence of “uremic gastroparesis.” Gastroenterology 104:A501, 1993

  4. Ravelli AM, Ledermann SE, Bisset WM, Trompeter RS, Barratt TM, Milla PJ: Foregut motor function in chronic renal failure. Arch Dis Child 67:1343–1347, 1992

    Google Scholar 

  5. Quintero E, Guth PH: Renal failure increases gastric mucosal blood flow and acid secretion in the rat: Role of endot-helium-derived nitric oxide. Am J Physiol 263:G75-G80, 1992

    Google Scholar 

  6. Quintero E, Kaunitz J, Nishizaki Y, De Giorgio R, Sternini C, Guth PH: Uremia increases gastric mucosal permeability and acid back-diffusion injury in the rat. Gastroenterology 103:1762–1768, 1992

    Google Scholar 

  7. Sanders K, Ward SM: Nitric oxide as a mediator of nonadrenergic noncholinergic neurotransmission. Am J Physiol 262:G379-G392, 1992

    Google Scholar 

  8. Desai KM, Sessa WC, Vane JR: Involvement of nitric oxide in the reflex relaxation of the stomach to accommodate food or fluid. Nature 351:477–479, 1991

    Google Scholar 

  9. Boeckxstaens GE, Pelckmans PA, Bogers JJ, Bult H, De Mann JG, Oosterbosch L, Herman AG, Van Maercke YM: Release of nitric oxide upon stimulation of nonadrenergic noncholinergic nerves in the rat gastric fundus. J Pharmacol Exp Ther 256:441–447, 1991

    Google Scholar 

  10. Lee LM, Purkerson ML, Agate FJ, Dempsey EW: Ultrastructural changes in renal glomeruli of rats during experimentally induced hypertension and uremia. Am J Anat 135:191–203, 1972

    Google Scholar 

  11. Robert A, Olafsson AS, Lancaster C, Zhang W-R: Interleukin-1 is cytoprotective, antisecretory, stimulates PGE2 synthesis by the stomach and retards gastric emptying. Life Sci 48:123–134, 1991

    Google Scholar 

  12. Raybould HE, Kolve E, Tache Y: Central nervous system action of calcitonin-gene-related peptide to inhibit gastric emptying. Peptides 9:735–737, 1988

    Google Scholar 

  13. Raybould HE, Roberts ME, Dockray GJ: Reflex decrease in intragastric pressure in response to cholecystokinin in the rat. Am J Physiol 253:G165-G170, 1987

    Google Scholar 

  14. Quintero E, Ohning G, Guth PH: Uremia in the rat affects gastric cell growth and differentiation. Dig Dis Sci (in press)

  15. Lefebrve RA, Hasrat J, Gobert A: Influence ofN G-nitro-l-arginine methyl ester on vagally induced gastric relaxation in the anesthetized rat. Br J Pharmacol 105:315–320, 1992

    Google Scholar 

  16. Li CG, Rand MJ: Nitric oxide and vasoactive intestinal polypeptide mediate non-adrenergic non-cholinergic inhibitory transmission to smooth muscle of the rat gastric fundus. Eur J Pharmacol 191:303–309, 1990

    Google Scholar 

  17. Plourde V, Quintero E, Suto G, Coimbra C, Tache Y: Delayed gastric emptying induced by inhibitors of nitric oxide synthase in rats. Eur J Pharmacol 256:125–129, 1994

    Google Scholar 

  18. Kelly KA: Gastric emptying of liquids and solids: role of proximal and distal stomach. Am J Physiol 239:G71-G75, 1980

    Google Scholar 

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Authors and Affiliations

  1. From the CURE/UCLA Digestive Diseases Center, VA Wadsworth Medical Center, Department of Medicine and Brain Research Institute, University of California, 90073, Los Angeles, California

    Helen E. Raybould PhD, Victor Plourde MD, Tilman Zittel MD, Jordi Bover MD & Enrique Quintero MD

Authors
  1. Helen E. Raybould PhD
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  2. Victor Plourde MD
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  3. Tilman Zittel MD
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  4. Jordi Bover MD
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  5. Enrique Quintero MD
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Additional information

This work was supported by NIH grant DDK 41004 (H.E.R.) and the CURE/UCLA Digestive Disease Core Center DDK 41031 (Animal and Gastrointestinal Blood Flow Cores). E.Q. was the recipient of a Fogarty International Fellowship Award (NIH 1 FO5 TWO4443-01) and a grant from the Conserja de Education, Cultura y Deportes of the Canary Islands Autonomous Government. J.B. was supported by a grant from Fondacio La Caixa, Spain.

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Raybould, H.E., Plourde, V., Zittel, T. et al. Gastric emptying of solids but not liquids is decreased in rats with chronic renal failure. Digest Dis Sci 39, 2301–2305 (1994). https://doi.org/10.1007/BF02087642

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  • DOI: https://doi.org/10.1007/BF02087642

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