Abstract
Experiences in experimental renal infection of rats treated with gentamycin, indomethacin, and by the combination of both drugs are reported. Urine osmolality of animals treated with combined therapy normalized after the first dose of indomethacin; their antibody titers against the pathogenic bacteria, as compared to the controls, decreased significantly. When drugs were administered separately the above immunologic changes could not be observed. Indomethacin did not inhibit the antibacterial effect of gentamycin and, administered alone, it increased the renal concentration ability.
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Aoki, S., Imamura, S., Aoki, M., McCabe, W. R.: Abacterial and bacterial pyelonephritis. Immunofluorescent localisation of bacterial antigen.New Engl. J. Med., 281, 1375 (1969).
Beregi, E., Hamvas, A., Rényi-Vámos, F.: Immunohistological studies in chronic pyelonephritis.Clin. Nephrol., 2 113 (1974).
Cameron, J. S.: Bright's disease today: The pathogenesis and treatment of glomerulonephritis. III.Brit. med. J., 4, 217 (1972).
Howard, R. S., Foster, E. A., Paquin, A. J.: Experimental descending Escherichia coli urinary tract infection: influence of specific immunization and chronic bladder neck obstruction.Invest. Urol., 3, 340 (1966).
Levison, S. P., Levison, M. E.: Effect of indomethacin and sodium meclophenamate on the renal concentrating defect in experimental enterococcal pyelonephritis in rats.J. Lab. Clin. Med., 88, 958 (1976).
Levison, S. P., Perlstein, D., Kay, D.: Influence of furosemide diuresis on antimicrobal treatment of pyelonephritis due to Escherichia coli.J. Inf. Dis., 128, 251 (1973).
Lum, G. M., Aisembrey, G. A., Dunn, M. J., Berl, T., Schrier, R. W., Keith, M., McDonald, M.: In vivo effect of indomethacin to potentiate the renal medullary cyclic AMP response to vasopressin.J. Clin. Invest., 59, 8 (1977).
Miller, T. E., North, D.: The cellular kinetics of the immune response in pyelonephritis.J. Lab. Clin. Med., 78, 891 (1971).
Nimmich, W., Budde, E., Haumann, G., Klinkmann, H.: Long-term study of humoral immune response in patients with chronic pyelonephritis.Clin. Nephrol., 6, 428 (1976).
O'Sullivan, D. J., Fitzgerald, M. G., Meynell, M. J., Malins, J. M.: A simplified method for the quantitative bacterial culture in the urine.J. Clin. Path., 13, 527 (1960).
Sanford, J. P., Hunter, B. W., Donaldson, P.: Localisation and fate of Escherichia coli in hematogenous pyelonephritis.J. exp. Med., 116, 285 (1962).
Schäfer, H. E.: Humorale Abwehrreaktionen bei bakterieller Pyelonephritis. In: v. Losse, H., Kienitz, M. (eds): Die Pyelonephritis. G. Thieme, Stuttgart 1966.
Tuan, H., Hagemann, J., Briedigkeit, H., Dutz, W.: Experimental pyelonephritis. Route of infection, course and immunological aspects.Int. Urol. Nephrol., 4, 285 (1972).
Túri, S., László, A., Mérth, I.: The indomethacin treatment of children with nephrogenous diabetes insipidus.Orv. Hetil., 121, 337 (1980).
Túri, S., Petheö, G., Szöllősi, E., Temesvári, P.: E. coli-Serumantikörper bei Pyelonephritis: ihre Untersuchung mit monovalenten O-Antigenen bekannter Serogruppen, mit polyvalenten und aus dem Urin der Kranken isolierten Antigenen.Acta paed. Acad. Sci. hung., 20, 199 (1989).
Vermylen, J., Dotremont, G., Gaetano, G. H., Donati, M. B., Michelsen, P.: Indomethacin and urinary excretion of fibrinogen-like material in proliferative glomerulonephritis.Rev. Eur. Etud. Clin. Biol., 15, 979 (1970).
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Túri, S., Sallai, J., Farkas, E. et al. Indomethacin and gentamycin treatment in experimental kidney infection. International Urology and Nephrology 14, 319–326 (1982). https://doi.org/10.1007/BF02081970
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DOI: https://doi.org/10.1007/BF02081970