Skip to main content
SpringerLink
Log in

Effect of endogenous cholecystokinin on postprandial gallbladder refilling

Ultrasonographic study in healthy subjects and in gallstone patients

  • Pancreatic And Biliary Disorders
  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

Abstract

The postprandial release of cholecystokinin (CCK) regulates gallbladder (GB) contraction but little is known about the role, if any, of the still-elevated CCK blood levels on subsequent GB refilling. To assess the role of CCK in GB refilling, a CCK-receptor antagonist, loxiglumide, or saline were infused intravenously in a random double-blind fashion after the ingestion of a liquid test meal in 16 healthy subjects. An identical study protocol was performed in 10 GB “contractor” patients with radiolucent stones to ascertain whether the reported reduced CCK effect on GB emptying also affects GB refilling. GB volumes were assessed ultrasonographically in the fasting state and for 150 min at 15-min intervals after meal ingestion. GB volumes during postprandial refilling were significantly greater during loxiglumide than placebo infusion (P<0.01), but they did not differ between gallstone and control subjects. In conclusion, postprandial endogenous CCK has a relevant role in delaying GB refilling, and this effect is not altered in patients with radiolucent gallstones.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Beglinger C, Freid M, Whitehouse I, Jansen JB, Lamers CB, Gyr K: Pancreatic enzyme response to a liquid meal and to hormonal stimulation. J Clin Invest 75:1471–1476, 1985

    PubMed  Google Scholar 

  2. Liddle RA, Goldfine ID, Williams JA: Bioassay of plasma cholecystokinin in rats: Effects of food, trypsin inhibitor, and alcohol. Gastroenterology 87:842–849, 1984

    Google Scholar 

  3. Lilja P, Fagan C, Wiener S, Inoue K, Watson LC, Rayford PL, Thompson JC: Infusion of pure CCK in humans: correlation between plasma concentrations of CCK and gallbladder size. Gastroenterology 83:256–261, 1982

    PubMed  Google Scholar 

  4. Maton PN, Selden AC, Fitzpatrick ML, Chadwick VS: Infusion of cholecystokinin octapeptide in man: relation between plasma cholecystokinin concentrations and gallbladder emptying rates. Eur J Clin Invest 14:37–41, 1984

    PubMed  Google Scholar 

  5. Hopman WPM, Kertens PJSM, Jansen JBMJ, Rosenbusch G, Lamers CBHW: Effects of graded physiologic doses of CCK on gallbladder contraction measured by ultrasonography. Gastroenterology 89:1242–1247, 1985

    PubMed  Google Scholar 

  6. Jensen RT, Garohner JD: Cholecystokinin receptor antagonistsin vitro. In Cholecystokinin Antagonists in Gastroenterology. Adler Beghinger (ed). Springer, 1991, pp 93–111

  7. Niederau C, Heintges T, Rovati L, Strohmeyer G: Effects of Loxiglumide on gallbladder emptying in healthy volunteers. Gastroenterology 97:1331–1336, 1989

    PubMed  Google Scholar 

  8. Fisher RS, Stelzer F, Rock E, Malmud LS: Abnormal gallbladder emptying in patients with gallstones. Dig Dis Sci 27:1019–1024, 1982

    PubMed  Google Scholar 

  9. Masclee AAM, Jansen JBMJ, Driessen WMM, Geuskens LM, Lamers CB: Plasma cholecystokinin and gallbladder response to intraduodenal fat in gallstone patients. Dig Dis Sci 34:353–359, 1989

    PubMed  Google Scholar 

  10. Upp JR, Nealon WH, Singh P, Fagan CJ, Jonas AS, Greeley GH, Thompson JC: Correlation of CCK receptors with gallbladder contractivity in patients with gallstones. Ann Surg 199:276–280, 1987

    Google Scholar 

  11. Thompson JC, Fried GM, Ogden WD, Fagan CJ, Inoue K, Wiener J, Watson LC: Correlation between release of CCK and contraction of the gallbladder in patients with gallstones. Ann Surg 195:670–675, 1982

    PubMed  Google Scholar 

  12. Lawson M, Everson GT, Klingensmith W, Kern F: Coordination of gastric and gallbladder emptying after ingestion of a regular meal. Gastroenterology 85:866–870, 1983

    PubMed  Google Scholar 

  13. Meyer BM, Beglinger C, Jansen JBMJ, Rovati LC, Werth A, Hildebrand P, Zach D, Stalder GA: Role of cholecystokinin in regulation of gastrointestinal motor functions. Lancet 1:12–15, 1989

    Google Scholar 

  14. Becker HD, Werner M, Schafmayer A: Release of radioimmunologic cholecystokinin in human subjects. Am J Surg 147:124–129, 1984

    PubMed  Google Scholar 

  15. Jansen JBMJ, Lamers CBHW: Radioimmunoassay of cholecystokinin in human tissue and plasma. Clin Chim Acta 131:305–316, 1983

    PubMed  Google Scholar 

  16. Walker JP, Khalil T, Wiener I, Fagan CJ, Townsend CM, Greeley GH, Thompson JC: The role of neurotensin in human gallbladder motility. Ann Surg 201:678–683, 1985

    PubMed  Google Scholar 

  17. Ryan J, Ryave S: Effect of vasoactive intestinal polypeptide on gallbladder smooth muscle in vitro. Am J Physiol 234:E44-E46, 1978

    PubMed  Google Scholar 

  18. Ryan J, Cohen S: Interaction of gastrin I, secretin and cholecystokinin on gallbladder smooth muscle. Am J Physiol 230:553–556, 1976

    PubMed  Google Scholar 

  19. Everson GT, Braverman DZ, Johnson ML, Kern F Jr: A critical evaluation of real-time ultrasound for the study of gallbladder volume and contraction. Gastroenterology 79:40–46, 1980

    PubMed  Google Scholar 

  20. Corazziari E, Ricci R, Biliotti D, Bontempo I, De Medici A, Pallotta N, Torsoli A: Oral administration of loxiglumide inhibits postprandial gallbladder contraction without affecting gastric emptying. Dig Dis Sci 35:50–54, 1990

    PubMed  Google Scholar 

  21. Pauletzki J, Cicala M, Holl J, Sauerbruch T, Schafmayer A, Paumgartner G: Correlation between gallbladder fasting volume and postprandial emptying in gallstone patients and healthy controls. Gut 34:1443–1447, 1993

    PubMed  Google Scholar 

  22. Bloom SR: Gastrointestinal hormones.In Gastrointestinal Physiology II. Vol 12. R Crane (ed). University Press, Baltimore, 1977, pp 71–103

    Google Scholar 

  23. Greenberg GR, McCloy RF, Adrian TE, Chadwick VS, Baron JH, Bloom SR: Inhibition of pancreas and gallbladder by pancreatic polypeptide. Lancet 2:1280–1282, 1978

    PubMed  Google Scholar 

  24. Adrian TE, Mitchenere P, Sagor G, Bloom SR: Effect of pancreatic polypeptide on gallbladder pressure and hepatic bile secretion. Am J Physiol 242:204–207, 1982

    Google Scholar 

  25. Conter RJ, Roslyn JJ, DenBesten L, Taylor IL: Pancreatic polypeptide enhances postcontractile gallbladder filling in the prairie dog. Gastroenterology 92:771–776, 1987

    PubMed  Google Scholar 

  26. Meier R, Hildebrand P, Thumshirn M, Albrecht C, Studer B, Gyr K, Beglinger C: Effect of loxiglumide, a cholecystokinin antagonist, on pancreatic polypeptide release in humans. Gastroenterology 99:1757–1762, 1990

    PubMed  Google Scholar 

  27. Liddle RA, Gertz BJ, Kanayama S, Beccaria L, Gettys TW, Taylor I, Rushakoff RJ, Williams VC, Coker LD: Regulation of pancreatic endocrine function by cholecystokinin: Studies with MK-329, a nonpeptide cholecystokinin receptor antagonist. J Clin Endocrinol Metab 70:1312–1318, 1990

    PubMed  Google Scholar 

  28. Festi D, Frabboni R, Bazzoli F, Sangermano A, Ronchi M, Rossi L, Parini P, Orsini M, Primerano AMM, Mazzella G, Aldini R, Roda E: Gallbladder motility in cholesterol gallstone disease. Gastroenterology 99:1779–1785, 1990

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. From the Cattedra di Gastroenterologia I e Servizio di Radiologia, II Clinica Medica, Università “La Sapienza”, Rome, Italy

    Michele Cicala MD,  Enrico Corazziari MD, Daniele Diacinti MD, Danilo Badiali MD & Aldo Torsoli MD (FRCP (Edin)

Authors
  1. Michele Cicala MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Enrico Corazziari MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Daniele Diacinti MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Danilo Badiali MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Aldo Torsoli MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cicala, M., Corazziari, E., Diacinti, D. et al. Effect of endogenous cholecystokinin on postprandial gallbladder refilling. Digest Dis Sci 40, 76–81 (1995). https://doi.org/10.1007/BF02063946

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02063946

Key words

Search

Navigation