Abstract
The effects of three ultraviolet excimer laser wavelengths on normal and atheromatous human cadaver aortic wall are presented. Ultraviolet radiation successfully ablates vessel wall; the dose response is greatest at 249 nm followed by 193 nm and 351 nm, where the effect is negligible for the equivalent energy dose. Wavelengths 249 and 193 nm have a selective effect on fibrous atheroma; ablation proceeds at a higher rate in this tissue. Non-linear effects observed at 249 nm may be due to thermal as well as photoablative mechanisms. In addition, blood samples were exposed to all three wavelengths and potassium concentrations were measured; the dose of energy required to produce tissue ablation may also produce significant haemolysis and hyperkalaemia at 249 and 193 nm but not with 351 nm. This finding may be important for coronary angioplasty but less so for peripheral work. The wavelength that produces the strongest dose response is 249 nm; this is the wavelength for which a fibre-optic delivery system should be developed.
Similar content being viewed by others
References
Srinivasan R, Wynne JJ, Blum SE. Action of far ultraviolet light on organic polymer films: applications to semiconductor technology.J Radiat Curing 1983,10:12–5
Koren G, Yeh JTC. Emission spectra, surface quality and mechanism of excimer laser etching at polyimide films.Appl Phys Lett 1984,44:1112–4
Trokel SL, Srinivasan R, Braren B. Excimer laser surgery of the cornea.Am J Ophthalmol 1983,96:710–5
Linsker R, Srinivasan R, Wynne JJ, Alonso DR. Far ultraviolet laser ablation of atherosclerotic lesions.Lasers Surg Med 1984,4:201–6
Abela GS, Normann S, Cohen D et al. Effects of CO2, Nd-YAG and Argon laser radiation on coronary atheromatous plaques.Am J Cardiol 1984,50:1199–205
Lee G, Ikeda RM, Theis JH et al. Acute and chronic complications of laser angioplasty: vascular wall damage and formation of aneurysms in the atherosclerotic rabbit.Am J Cardiol 1984,53:290–3
Abela GS, Normann SJ, Cohen DM et al. Laser recanalisation of occluded atherosclerotic arteries in vivo and in vitro.Circulation 1985,71:403–11
Bowker TJ, Bown SG, Poole-Wilson PA et al. Quantitative comparative analysis of Argon and Nd-YAG laser radiation of normal and atheromatous arterial walls.Br Heart J 1985,53:101
Bowker TJ, Fox KM, Poole-Wilson et al. Acute and chronic angiographic effects of in vivo coronary laser angioplasty.Br Heart J 1986:in press
Choy DSJ, Stertzer SH, Rotterdam HZ, Bruno MS. Laser coronary angioplasty: experience with nine cadaver hearts.Am J Cardiol 1982,50:1209–11
Ginsberg R, Kim DS, Guthaner D, Toth J, Mitchell RS. Salvage of an ischemie limb by laser angioplasty: description of a new technique.Clin Cardiol 1984,7:54–8
Geschwind HJ, Boussignac G, Teissiere B et al. Conditions for effective Nd-YAG laser angioplasty.Br Heart J 1984,52:484–9
Cross FW, Mills TN, Bown SG. Pulsed Nd-YAG laser effects on normal and atheromatous aorta in vitro.Lasers Surg Med 1985:in press (Abstr)
Grundfest W, Litvack F, Forrester J, Fishbein M, Morgenstern L. Pulsed ultraviolet lasers provide precise control of atheroma ablation.Circulation 1984,70:11–35 (Abstr)
Isner JM, Clarke RH, Donaldson RF et al. The excimer laser: gross, light microscopic, and ultrastructural analysis of potential advantages for use in laser therapy of cardiovascular disease.Circulation 1984,70:11–35 (Abstr)
Lane R, Linsker R, Wynne JJ, Torres A. Ultraviolet laser ablation of skin. IBM Research Report 1984; RC 10379
Isner JM, Clarke RH. The current status of lasers in the treatment of cardiovascular disease. IEEE (Inst Electr Electron Eng) J Quantum Electron 1984, QE-20:1406–19
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bowker, T.J., Cross, F.W., Rumsby, P.T. et al. Excimer laser angioplasty: Quantitative comparison in vitro of three ultraviolet wavelengths on tissue ablation and haemolysis. Laser Med Sci 1, 91–100 (1986). https://doi.org/10.1007/BF02038956
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02038956