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A protective action of disodium cromoglycate against the contraction of guinea-pig ileum induced by various pharmacological stimulants

  • Histamine and Kinins
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Abstract

The effect of disodium cromoglycate (DSCG) on the contraction of isolated guinea-pig ileum induced by histamine, acetylcholine and serotonin has been investigated. DSCG protected ileum against all agents tested. The action of DSCG at concentrations of 10−3 to 10−2 M was both dose- and time-dependent. Furthermore, DSCG inhibited compound 48/80-induced histamine release from isolated mast cells over the same range of concentrations.

The anti-histaminic action of DSCG was reversible and after 2 h the ileum responded normally to histamine.

DSCG-induced inhibition of the contractile response to histamine could be overcome by increasing concentrations of histamine but not by extracellular calcium.

A mechanism of the action of DSCG, either against the contraction of ileal smooth muscle or against histamine release from mast cells, is discussed with a view to the inhibition of the utilization of calcium ions by both cells.

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Authors and Affiliations

  1. Department of Biogenic Amines, Institute of Pharmacology, Cracow, 90-136, Łódź, Polland

    Wacław Kazimierczak,  Ricardo Gonzalez Alvarez (recipient of Polish Government Fellowship) & Czeslaw Maśliński

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  1. Wacław Kazimierczak
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  2. Ricardo Gonzalez Alvarez
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  3. Czeslaw Maśliński
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This work was supported by the Polish Academy of Sciences, Grant No. 10.5.

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Kazimierczak, W., Alvarez, R.G. & Maśliński, C. A protective action of disodium cromoglycate against the contraction of guinea-pig ileum induced by various pharmacological stimulants. Agents and Actions 10, 8–14 (1980). https://doi.org/10.1007/BF02024172

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  • DOI: https://doi.org/10.1007/BF02024172

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