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Slow-reacting substances and their formation by a lipoxygenase pathway

  • Histamine and Kinins Immunosuppression and Inflammation
  • Lipoxygenase Products: Release and Activities
  • Published:
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Abstract

Slow-reacting substances are formed from arachidonic acid by the action of a lipoxygenase, which leads to the formation of 5-hydroperoxy,6,8,11,14 eicosatetraenoic acid.

The covalent structures of SRS-A from guinea-pig lung and SRS from RBL-1 cells have been determined by protein chemical analysis and electron impact mass spectrometry of a derivative of the intact molecules. The structures of SRS-A and SRS are identical, being 5-hydroxy-6-cysteinyl-glycinyl-7,9,11,14-eicosatetraenoic acid.

SRSs may be formed by a combination of the metabolism of arachidonic acid by the lipoxygenase pathway and the glutathione detoxification pathway involving nucleophilic attack on 5,6-oxidoeicosatetraenoic acid.

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Authors and Affiliations

  1. Department of Pharmacology, Institute of Basic Medical Sciences, Royal College of Surgeons of England, Lincoln's Inn Fields, WC2A 3PN, London

    Priscilla J. Piper, Marwa N. Samhoun & J. R. Tippins

  2. Department of Biochemistry, Imperial College, SW7, London, UK

    H. R. Morris & G. W. Taylor

Authors
  1. Priscilla J. Piper
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  2. Marwa N. Samhoun
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  3. J. R. Tippins
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  4. H. R. Morris
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  5. G. W. Taylor
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Piper, P.J., Samhoun, M.N., Tippins, J.R. et al. Slow-reacting substances and their formation by a lipoxygenase pathway. Agents and Actions 10, 541–547 (1980). https://doi.org/10.1007/BF02024161

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