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Modulation of the intracellular and H3-histamine receptors and chemically-induced seizures in mice

  • Histamine and the Central Nervous System
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Abstract

Central histaminergic modulation of H1 rather than H2-receptors has been shown to modify epileptic activity. Compounds acting on the HIC- and H3-receptors were tested against chemically-induced seizures in mice. Compounds antagonising the microsomal and nuclear intracellular receptors (HIC) only modified seizures at doses where toxicity was observed. Antagonists of the histamine H3-receptor (thioperamide and burimamide) only potentiated the severity of clonic convulsions induced by picrotoxin, while impromidine (i.c.v.), an antagonist with H2-agonist activity, inhibited leptazol-induced seizures. The H3-agonist, (R)α-methylhistamine, potentiated chemically-induced seizures, but at lower doses there was slight inhibition.

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Authors and Affiliations

  1. Neuropharmacology Research Group, Department of Life Sciences, University of East London, Romford Road, E15 4LZ, London, UK

    G. Sturman, P. Freeman, H. M. Meade & N. A. Seeley

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  1. G. Sturman
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  2. P. Freeman
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  3. H. M. Meade
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  4. N. A. Seeley
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Sturman, G., Freeman, P., Meade, H.M. et al. Modulation of the intracellular and H3-histamine receptors and chemically-induced seizures in mice. Agents and Actions 41 (Suppl 1), C68–C69 (1994). https://doi.org/10.1007/BF02007771

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  • DOI: https://doi.org/10.1007/BF02007771

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