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Histamine and tryptase in serum of patients after coronary surgery: influence of pretreatment with methylprednisolone

  • Histamine and Clinical Studies and Models
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Abstract

The presence of histamine and tryptase in serum during and after coronary artery bypass grafting may be an indication for the induction of inflammation. One group of patients received no glucocorticoids, a second one received methylprednisolone before extracorporeal circulation. In the steroid group, no effects were seen on the basal levels of histamine and tryptase. In the other group, two peak levels of histamine were observed, one peak 10 minutes after starting extracorporeal circulation and another peak 4 hours post-surgery. In this group, tryptase was only elevated during the period of extracorporeal circulation. There were no differences between both groups in complement activation. It was concluded that during surgery mast cells were activated but, since tryptase levels decreased in the post-operative period, the increase in histamine level can only be explained by activation of basophils.

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Author notes

  1. F. J. van Overveld

    Present address: Dept. of Medicine, University of Antwerp (UIA), Universiteitsplein 1, B-2610, Antwerp, Belgium

Authors and Affiliations

  1. Dept. of Medicine, University of Antwerp (UIA), Universiteitsplein 1, B-2610, Antwerp, Belgium

    R. F. De Jongh, P. G. Jorens, P. Walter, L. Bossaert & W. A. De Backer

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  1. F. J. van Overveld
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  2. R. F. De Jongh
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  3. P. G. Jorens
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  4. P. Walter
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  5. L. Bossaert
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  6. W. A. De Backer
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van Overveld, F.J., De Jongh, R.F., Jorens, P.G. et al. Histamine and tryptase in serum of patients after coronary surgery: influence of pretreatment with methylprednisolone. Agents and Actions 38, C278–C280 (1993). https://doi.org/10.1007/BF01996485

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  • DOI: https://doi.org/10.1007/BF01996485

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