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Histamine is a transient marker of small intestinal injury induced by luminal acetic acid and casein

  • Non-Rheumatic Inflammatory Diseases
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Abstract

We compared the time course of histamine release with other markers of intestinal injury in a rabbit model of necrotizing enterocolitis. Injury was induced by luminal acetic acid (200 mM) and casein (10 mg/ml) and experiments terminated after 45 min or 3 hr. Compared to saline controls there was a significant elevation of epithelial permeability (51Cr-EDTA clearance) and luminal protein levels at both time points. Luminal fluid histamine levels were approximately 120-fold greater than saline controls at 45 min but were indistinguishable from control values at 3 hr. We conclude that although mast cell activation is a characteristic of this model, elevations in histamine levels are transient.

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Authors and Affiliations

  1. Department of Pediatrics, Louisiana State University School of Medicine, 1542 Tulane Ave., 70112-2822, New Orleans, LA, USA

    M. J. S. Miller, X. -J. Zhang, X. Gu, H. Sadowska-Krowicka & D. A. Clark

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  1. M. J. S. Miller
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  2. X. -J. Zhang
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  3. X. Gu
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  4. H. Sadowska-Krowicka
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  5. D. A. Clark
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Miller, M.J.S., Zhang, X.J., Gu, X. et al. Histamine is a transient marker of small intestinal injury induced by luminal acetic acid and casein. Agents and Actions 34, 175–177 (1991). https://doi.org/10.1007/BF01993270

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