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Dietary carotenoids block photocarcinogenic enhancement by benzo (a)pyrene and inhibit its carcinogenesis in the dark

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Summary

The carotenoids β-carotene (C) and canthaxanthine (CX), with and without pro-vitamin A activity, respectively, when perorally administered to mice, markedly prevent benzo(a)pyrene photocarcinogenic enhancement (BP-PCE), continue to block such BP-PCE and protect significantly against BP carcinogenesis in mice maintained in the dark. These results appear relevant to both the pathogenesis of chemical carcinogenesis and rational programs of skin cancer prevention in humans.

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Authors and Affiliations

  1. ‘C. Golgi’ Institute of General Pathology, Centro Profilassi Prevenzione Diagnosi e Cura dei Tumori, University of Pavia, I-27100, Pavia, Italy

    L. Santamaria, A. Bianchi, A. Arnaboldi, L. Andreoni & P. Bermond

  2. Institute of Pharmacology II, University of Pavia, I-27100, Pavia, Italy

    L. Santamaria, A. Bianchi, A. Arnaboldi, L. Andreoni & P. Bermond

  3. Centre Hospitalier, F-51100, Reims, France

    L. Santamaria, A. Bianchi, A. Arnaboldi, L. Andreoni & P. Bermond

Authors
  1. L. Santamaria
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  2. A. Bianchi
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  3. A. Arnaboldi
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  4. L. Andreoni
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  5. P. Bermond
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Additional information

This investigation was partially supported, first, by the Consiglio Nazionale delle Ricerche, Roma, contr. No. 81.01808.04, and then by the Ministero della Sanità, Roma, through the Centro Tumori, Cap 2543, 12 Dec. 1981.

Acknowledgments. We thank Dr G. Klêcak, Hoffmann-La Roche, Inc. for his technical advice and profitable discussion, and Hoffmann-La Roche management for the gift of carotenoids and assistance with expenses. We acknowledge Professor A.C. Hollinshead for information about State and local regulations on occupational safety and health in relation to UV and visible sun light.

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Santamaria, L., Bianchi, A., Arnaboldi, A. et al. Dietary carotenoids block photocarcinogenic enhancement by benzo (a)pyrene and inhibit its carcinogenesis in the dark. Experientia 39, 1043–1045 (1983). https://doi.org/10.1007/BF01989795

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  • DOI: https://doi.org/10.1007/BF01989795

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