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Effect of alloimmunized thymic cells on isolated mouse atria. Participation of prostaglandins

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Summary

The effects of thymic cells from alloimmunized mice on the mechanical activity of isolated mouse atria were explored. Immune cells decreased the tension without changing the rate of beating of the atrium. After inhibition of prostaglandin synthesis with indomethacin and acetylsalicylic acid, the negative inotropic action of alloimmunized thymic cells was blocked.

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Authors and Affiliations

  1. Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Serrano 665/69, 1414, Buenos Aires, Argentina

    A. M. Genaro, G. A. Cremaschi, M. E. Sales & E. S. Borda

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  1. A. M. Genaro
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  2. G. A. Cremaschi
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  3. M. E. Sales
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  4. E. S. Borda
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Additional information

This work has been supported by grant 6638 from CONICET (Argentina) and we thank Dr Marta Braun for her advice and helpful discussions.

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Genaro, A.M., Cremaschi, G.A., Sales, M.E. et al. Effect of alloimmunized thymic cells on isolated mouse atria. Participation of prostaglandins. Experientia 39, 1033–1035 (1983). https://doi.org/10.1007/BF01989789

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  • DOI: https://doi.org/10.1007/BF01989789

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