Abstract
Diclofenac and its derivative nitrofenac were compared to test their anti-inflammatory efficacy and gastrointestinal toxicity in rats.
A similar good anti-inflammatory activity of the two drugs was observed in carrageenan oedema and a marked gastrointestinal toxicity was induced by diclofenac, while nitrofenac failed to produce gastric damage even with very high doses (50 and 100 mg/kg).
The lack of the gastric ulcers in rats treated with nitrofenac could be due to the absorption of the drug as an inactive inhibitor of PG synthesis and/or to the fact that probably nitric oxide is release in the intestine and plays an important protective role in maintaining the tissue integrity.
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Conforti, A., Donini, M., Brocco, G. et al. Acute anti-inflammatory activity and gastrointestinal tolerability of diclofenac and nitrofenac. Agents and Actions 40, 176–180 (1993). https://doi.org/10.1007/BF01984058
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DOI: https://doi.org/10.1007/BF01984058