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Effects of gold sodium thiomalate, cyclosporin A, cyclophosphamide, and placebo on collagen-induced arthritis in rats

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Abstract

The prophylactic and therapeutic effects of gold sodium thiomalate, cyclosporin A, cyclophosphamide, and placebo on collagen-induced arthritis (CIA) were evaluated in DA rats. Prophylactic treatment with cyclosporin A and cyclophosphamide suppressed the arthritis incidence, clinical inflammation, destructive bone changes, and development of anti-collagen antibody in DA rats subsequently injected with porcine type-II collagen. Therapeutic treatment with cyclosporin A and cyclophosphamide had a definite suppression on established CIA when started 21 days after the initial collagen injection, but the suppression was less marked than that of prophylactic treatment. Gold had no impact on CIA in DA rats when administered either prophylactically or therapeutically.

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References

  1. M. Cremer,Type II collagen-induced arthritis in rats. InHandbook of Animal Models for the Rheumatic Disease Volume 1. (Eds. R. A. Greenwald and H. S. Diamond) pp. 17–27, CRC Press, Boca Raton, FL 1988.

    Google Scholar 

  2. M. M. Griffiths, E. J. Eichwald, J. H. Martin, C. B. Smith and C. W. DeWitt,Immunogenetic control of experimental type II collagen-induced arthritis. I. Susceptibility and resistance among inbred strains of rats. Arth. Rheum.24, 781–789 (1981).

    Google Scholar 

  3. M. M. Griffiths and C. W. DeWitt,Immunogenetic control of experimental collagen-induced arthritis in rats. II. ECIA susceptibility and immune response to type II collagen (calf) are linked to RT1. J. Immunogen.8, 463–470 (1981).

    Google Scholar 

  4. C. Arita, N. Kaibara, T. Hotokebuchi, K. Takagishi and K. Arai,Effect of cyclophosphamide and its analogs on collagen arthritis in rats. Clin. Immunol. Immunopathol.43, 354–361 (1987).

    Google Scholar 

  5. K. Komoriya, I. Nagata, K. Kunisawa, T. Takeshita, and N. Tatsuyuki,Anti-arthritic and immunoregulatory effects of TI-31 on collagen-induced arthritis. Jap. J. Pharmacol.45, 389–396 (1987).

    Google Scholar 

  6. J. M. Stuart, L. K. Myers, A. S. Townes and A. H. Kang,Effect of cyclophosphamide, hydrocortisone, and levamisole on collagen-induced arthritis in rats. Arth. Rheum.24. 790–794 (1981).

    Google Scholar 

  7. A. E. Sloboda, J. E. Birnbaum, A. L. Oronsky and S. S. Kerwar,Studies on type II collagen-induced polyarthritis in rats. Effect of anti-inflammatory and anti-rheumatic agents. Arth. Rheum.24, 616–624 (1981).

    Google Scholar 

  8. A. W. Probert Jr., D. J. Schrier and R. B. Gilbertsen,Effects of antiarthritic compounds on type II collagen-induced arthritis in rats. Arch. Int. Pharm.269, 167–176 (1984).

    Google Scholar 

  9. K. Yamaki, H. Nakagawa and S. Tsurufuji,Inhibitory effects of anti-inflammatory drugs on type II collagen induced arthritis in rats. Ann. Rheum. Dis.46, 543–548 (1987).

    Google Scholar 

  10. S. S. Kerwar and A. E. Sloboda,Studies on the effect of fenbufen and sulindac on type II collagen-included arthritis in rats. Agents and Actions12, 216–220 (1982).

    Google Scholar 

  11. G. W. Cannon and D. S. Harper,The effects of flurbiprofen on the passive transfer of adjuvant-induced arthritis. Agents and Actions35, 64–70 (1992).

    Google Scholar 

  12. R. P. Carlson, L. J. Datko, L. O'Neill-Davis, E. M. Blazek, F. DeLustro, R. Beideman and A. J. Lewis,Comparison of inflammatory changes in established type II collagen- and adjuvant-induced arthritis using outbred Wistar rats. Int. J. Immunopharmacol.7, 811–826 (1985).

    Google Scholar 

  13. A. J. Lewis, R. P. Carlson, J. Chang and F. DeLustro,Effect of gold salts,d-penicillamine and benoxaprofen on type II collagen-induced arthritis in rats. Agents and Actions14, 707–714 (1984).

    Google Scholar 

  14. K. Phadke, J. Carroll and S. Nanda,Effects of various anti-inflammatory drugs on type II collagen-induced arthritis in rats. Clin. Exp. Immunol.47, 579–586 (1982).

    Google Scholar 

  15. W. J. McCune, D. E. Trentham and J. R. David,Gold does not alter the arthritic, humoral, or cellular responses in rats with type II collagen-induced arthritis. Arth. Rheum.23, 932–936 (1980).

    Google Scholar 

  16. N. Kaibara, T. Hotokebuchi, K. Takagishi and I. Katsuki,Paradoxical effects of cyclosporin A on collagen arthritis in rats. J. Exp. Med.158, 2007–2015 (1983).

    Google Scholar 

  17. E. Brahn, D. J. Peacock and M. L. Banquerigo,Suppression of collagen-induced arthritis by combination cyclosporin A and methotrexate therapy. Arth. Rheum.34, 1282–1288 (1991).

    Google Scholar 

  18. L. R. Garrett, M. W. Whitehouse, B. Vernon-Roberts and P. M. Brooks,Ambivalent properties of gold drugs in adjuvant induced polyarthritis in rats. J. Rheumatol.12, 1079–1082 (1985).

    Google Scholar 

  19. A. J. Lewis, J. Cottney, D. D. White, P. K. Fox, A. McNeillie, J. Dunlop, W. E. Smith and D. H. Brown,Action of gold salts in some inflammatory and immunological models. Agents and Actions10, 63–76 (1980).

    Google Scholar 

  20. G. W. Cannon, S. McCall, B. C. Cole, M. M. Griffiths, L. A. Radov and J. R. Ward,Effects of indomethacin, cyclosporin, cyclophosphamide, and placebo on collagen-induced arthritis of mice. Agents and Actions29, 315–323 (1990).

    Google Scholar 

  21. G. W. Cannon, C. B. Smith, B. D. Cole and J. R. Ward,Effects of weekly and daily pretreatment with gold sodium thiomalate on adjuvant-induced arthritis. J. Rheumatol.14, 202–208 (1987).

    Google Scholar 

  22. B. B. Newbould,Chemotherapy of arthritis induced in rats by mycobacterial adjuvant. Brit. J. Pharmacol.21, 127–136 (1963).

    Google Scholar 

  23. D. T. Walz, M. J. DiMartino and A. Misher,Suppression of adjuvant-induced arthritis in the rat by gold sodium thiomalate. Ann. Rheum. Dis.30, 303–306 (1971).

    Google Scholar 

  24. R. D. Sofia and J. F. Douglas,The prophylactic and therapeutic effects of gold sodium thiomalate against adjuvant-induced pylarthritis in rats. Agents and Actions3, 335–339 (1973).

    Google Scholar 

  25. E. Arrigoni and M. E. Bramm,Investigations on the influence of cyclophosphamide, gold sodium thiomalate and d-penicillamine on nystatin oedema and adjuvant arthritis. Agents and Actions5, 264–265 (1975).

    Google Scholar 

  26. R. D. Sofia, L. C. Knobloch and J. F. Douglas,Effect of concurrent administration of aspirin, indomethacin or hydrocortisone with gold sodium thiomalate against adjuvant-induced arthritis in rat. Agents and Actions6, 728–734 (1976).

    Google Scholar 

  27. D. T. Walz, J. DiMartino, L. W. Chakrin, B. M. Sutton and A. Misher,Antiarthritic properties and unique pharmacologic profile of a potential chrysotherapeutic agent, SK&FD-39162. J. Pharmacol. Exp. Ther.197, 142–151 (1976).

    Google Scholar 

  28. K. Takagishi, N. Kaibara, T. Hotokebuchi, C. Arita, M. Morinaga and K. Arai,Effects of cyclosporin on collagen induced arthritis in mice. Ann. Rheum. Dis.45, 339–344 (1986).

    Google Scholar 

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Authors and Affiliations

  1. Veterans Affairs Medical Center, University of Utah School of Medicine, 500 Foothill Dr., 84148, Salt Lake City, UT, USA

    Grant W. Cannon M.D. (Associate Chief of Staff for Education (11E), Shawna McCall & Marie M. Griffiths

  2. Division of Rheumatology, Department of Internal Medicine, University of Utah School of Medicine, 500 Foothill Dr., 84148, Salt Lake City, UT, USA

    Grant W. Cannon M.D. (Associate Chief of Staff for Education (11E), Barry C. Cole, John R. Ward & Marie M. Griffiths

  3. Fison Pharmaceuticals, Rochester, New York, USA

    Lesley A. Radov

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  1. Grant W. Cannon M.D.
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  2. Shawna McCall
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Cannon, G.W., McCall, S., Cole, B.C. et al. Effects of gold sodium thiomalate, cyclosporin A, cyclophosphamide, and placebo on collagen-induced arthritis in rats. Agents and Actions 38, 240–246 (1993). https://doi.org/10.1007/BF01976216

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  • DOI: https://doi.org/10.1007/BF01976216

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