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Nutrient metabolism in islet cells

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References

  1. Ågren, A., Brolin, S.E., and Hellerström, C., Glucose phosphorylation and insulin release of the pancreatic islets from new born rats. Diabetologia11 (1975) 329.

    Article  Google Scholar 

  2. Ashcroft, S.J.H., Glucoreceptor mechanisms and the control of insulin release and biosynthesis. Diabetologia18 (1980) 5–15.

    Article  PubMed  Google Scholar 

  3. Ashcroft, S.J.H., Capito, K., and Hedeskov, C.J., Time course studies of glucose-induced changes in glucose-6-phosphate and fructose-1,6-diphosphate content of mouse and rat pancreatic islets. Diabetologia9 (1973) 299–302.

    Article  PubMed  Google Scholar 

  4. Ashcroft, S.J.H., Hedeskov, C.J., and Randle, P.J., Glucose metabolism in mouse pancreatic islets. Biochem. J.118 (1970) 143–154.

    PubMed  Google Scholar 

  5. Ashcroft, S.J.H., and Randle, P.J., Glucose-6-phosphatase activity of mouse pancreatic islets. Nature219 (1968) 857–858

    PubMed  Google Scholar 

  6. Ashcroft, S.J.H., and Randle, P.J., Enzymes of glucose metabolism in normal mouse pancreatic islets. Biochem. J.119 (1970) 5–15.

    PubMed  Google Scholar 

  7. Ashcroft, S.J.H., Weerasinghe, L.C.C., Bassett, J.M., and Randle, P.J., The pentose cycle and insulin release in mouse pancreatic islets. Biochem. J.126 (1972) 525–532.

    PubMed  Google Scholar 

  8. Ashcroft, S.J.H., Weerasinghe, L.C.C., and Randle, P.J., Interrelationship of islet metabolism, adenosine triphosphate content and insulin release. Biochem. J.132 (1973) 223–231.

    PubMed  Google Scholar 

  9. Berne, C., The metabolism of lipids in mouse pancreatic islets. The oxidation of fatty acids and ketone bodies. Biochem. J.152 (1975) 661–666.

    PubMed  Google Scholar 

  10. Berne, C., The metabolism of lipids in mouse pancreatic islets. The biosynthesis of triacylglycerols and phospholipids. Biochem. J.152 (1975) 667–673.

    PubMed  Google Scholar 

  11. Brolin, S.E., and Berne, C., The enzymatic activities of the initial glycolytic steps in pancreatic islets and acini. Metabolism16 (1967) 1024–1028.

    Article  PubMed  Google Scholar 

  12. Brolin, S.E., Berne, C., and Linde, B., Measurements of the enzymatic activities required for ATP formation by glycolysis in the pancreatic islets of hyperglycemic mice (NZO). Diabetes16 (1967) 21–25.

    PubMed  Google Scholar 

  13. Burch, P.T., Trus, M.D., Berner, D.K., Leontire, A., Zawalich, K.C., and Matschinsky, F.M., Adaptation of glycolytic enzymes. Glucose use and insulin release in rat pancreatic islets during fasting and refeeding. Diabetes30 (1981) 923–928.

    PubMed  Google Scholar 

  14. Christensen, H.N., Hellman, B., Lernmark, Å., Sehlin, J., Tager, H.S., and Täljedal, I.-B., In vitro stimulation of insulin release by nonmetabolizable, transport-specific amino acids. Biochim. biophys. Acta241 (1971) 341–348.

    PubMed  Google Scholar 

  15. Colca, J.R., Kotagal, N., Lacy, P.E., and McDaniel, M.L., Modulation of active Ca2+ uptake by the islet-cell endoplasmic reticulum. Biochem. J.212 (1983) 113–121.

    PubMed  Google Scholar 

  16. Dufrane, S., Malaisse, W.J., and Sener, A., Aldose reductase activity in pancreatic islets. Diabetologia25 (1983) 152.

    Google Scholar 

  17. Dufrane, S.P., Malaisse, W.J., and Sener, A., A micromethod for the assay of aldose reductase, its application to pancreatic islets. Biochem. Med., in press (1984).

  18. Formby, B., Capito, K., Egeberg, J., Hedeskov, C.J., Ca-activated ATPase activity in subcellular fractions of mouse pancreatic islets. Am. J. Physiol.230 (1976) 441–448.

    PubMed  Google Scholar 

  19. Frankel, B.J., Gylfe, E., Hellman, B., Idahl, L.-A., Landstrom, U., Lovtrup, S., and Sehlin, J., Metabolism of a cold-stored pancreatic islets. Diabetologia15 (1978) 187–190.

    Article  PubMed  Google Scholar 

  20. Giroix, M.-H., Dufrane, S.P., Malaisse-Lagae, F., Sener, A., and Malaisse, W.J., Fasting-induced impairment of glucose 1,6-bisphospate synthesis in pancreatic islets. Biochem. biophys. Res. Commun.119 (1984) 543–548.

    Article  PubMed  Google Scholar 

  21. Giroix, M.-H., Sener, A., Pipeleers, D.G., and Malaisse, W.J., Hexose metabolism in pancreatic islets: inhibition of hexokinase. Biochem. J., in press (1984).

  22. Graf, R., and Klessen, C., Glycogen in pancreatic islets of steroid diabetic rats. Carbohydrate histochemical detection and localization using and immunocytochemical technique. Histochemistry73 (1981) 225–232.

    Article  PubMed  Google Scholar 

  23. Gylfe, E., and Hellman, B., Role of glucose as a regulator and precursor of amino acids in the pancreatic β-cells. Endocrinology94 (1974) 1150–1156.

    PubMed  Google Scholar 

  24. Halban, P.A., Praz, G.A., and Wollheim, C.B., Abnormal glucose metabolism accompanies failure of glucose to stimulate insulin release from a rat pancreatic cell line (RINm5F). Biochem. J.212 (1983) 439–443.

    PubMed  Google Scholar 

  25. Hedeskov, C.J., Mechanism of glucose-induced insulin secretion. Physiol. Rev.60 (1980) 442–509.

    PubMed  Google Scholar 

  26. Hedeskov, C.J., and Capito, K., The effect of starvation on insulin secretion and glucose metabolism in mouse pancreatic islets. Biochem. J.140 (1974) 423–433.

    PubMed  Google Scholar 

  27. Hedeskov, C.J., and Capito, K., The pentose cycle and insulin release in isolated mouse pancreatic islets. Biochem. J.152 (1975) 571–576.

    PubMed  Google Scholar 

  28. Hedeskov, C.J., Hertz, L., and Nissen, C., The effect of mannoheptulose on glucose and pyruvate-stimulated oxygen uptake in normal mouse pancreatic islets. Biochim. biophys. Acta261 (1972) 388–397.

    Google Scholar 

  29. Hellerström, C., Effects of carbohydrates on the oxygen consumption of isolated pancreatic islets of mice. Endocrinology81 (1967) 105–112.

    PubMed  Google Scholar 

  30. Hellman, B., and Idahl, L.-A., Presence and mobilization of glycogen in mammalian pancreatic beta cells. Endocrinology84 (1969) 1–8.

    PubMed  Google Scholar 

  31. Hellman, B., Idahl, L.-A., Sehlin, J., and Täljedal, I.-B., Influence of anoxia on glucose metabolism in pancreatic islets: lack of correlation between fructose-1,6-diphosphate and apparent glycolytic flux. Diabetologia11 (1975) 495–500.

    Article  PubMed  Google Scholar 

  32. Hellman, B., Sehlin, J., and Täljedal, I.-B., Evidence for mediated transport of glucose in mammalian pancreatic beta-cells. Biochim. biophys. Acta241 (1971) 147–154.

    PubMed  Google Scholar 

  33. Hutton, J.C., Secretory granules. Experientia40 (1984) 1091–1098.

    PubMed  Google Scholar 

  34. Hutton, J.C., and Malaisse, W.J., Dynamics of O2 consumption in rat pancreatic islets. Diabetologia18 (1980) 395–405.

    PubMed  Google Scholar 

  35. Idahl, L.-A., Dynamics of pancreatic beta-cell responses to glucose. Diabetologia9 (1973) 403–412.

    Article  PubMed  Google Scholar 

  36. Idahl, L.-A., Glycolytic intermediates and signals for carbohydrate-induced insulin release. Horm. Metab. Res., suppl.10 (1980) 20–26.

    Google Scholar 

  37. Idahl, L.-A., and Hellman, B., Regulation of pancreatic beta-cell glycogen through cyclic-3,5-AMP. Diabetologia7 (1971) 139–142.

    Article  PubMed  Google Scholar 

  38. Idahl, L.-A., Hurme, P., Wahlquist, Y. and Hellman, B., Pancreatic beta-cell function and content of 6-phosphogluconate. Horm. Metab. Res.3 (1971) 141–144.

    PubMed  Google Scholar 

  39. Kasson, B.G., and Levin, S.R., Characterization of pancreatic islet Ca2+-ATPase. Biochim. biophys. Acta662 (1981) 30–35.

    PubMed  Google Scholar 

  40. Kawazu, S., Sener, A., Couturier, E., and Malaisse, W.J., Metabolic, cationic and secretory effects of hypoglycemic sulfonylureas in pancreatic islets. Naunyn-Schmiedeberg's Arch. Pharmac.312 (1980) 277–283.

    Article  Google Scholar 

  41. Kemmler, W., and Löffler, G., NaK-ATPase in rat pancreatic islets. Diabetologia13 (1977) 235–238.

    PubMed  Google Scholar 

  42. Kotagal, N., Colca, J.R., and McDaniel, M.L., Activation of an islet cell plasma membrane (Ca2++Mg2+)-ATPase by calmodulin and Ca-EGTA. J. biol. Chem.258 (1983) 4808–4813.

    PubMed  Google Scholar 

  43. Lenzen, S., and Panten, U., 2-oxocarboxylic acids and function of pancreatic islets in obese-hyperglycaemic mice. Insulin secretion in relation to45Ca uptake and metabolism. Biochem. J.186 (1980) 135–144.

    PubMed  Google Scholar 

  44. Levin, S.R., Kasson, B.G., and Driessen, J.F., Adenosine triphosphatases of rat pancreatic islets. Comparison with those of rat kidney. J. clin. Invest.62 (1978) 692–701.

    PubMed  Google Scholar 

  45. Lundquist, I., Acid amyloglucosidase and carbohydrate regulation. I. Effect of exogenous amyloglucosidase on tissue glycogen, blood glucose and plasma insulin. Horm. Metab. Res.4 (1972) 151–158.

    PubMed  Google Scholar 

  46. Lundquist, I., Acid amyloglucosidase and carbohydrate regulation. II. Acid amyloglucosidase activity in the endocrine pancreas. Horm. Metab. Res.4 (1972) 245–249.

    PubMed  Google Scholar 

  47. MacDonald, M.J., High content of mitochondrial glycerol-3-phosphate dehydrogenase in pancreatic islets and its inhibition by diazoxide. J. biol. Chem.256 (1981) 8287–8290.

    PubMed  Google Scholar 

  48. MacDonald, M.J., Calcium activation of pancreatic islet mitochondrial glycerol phosphate dehydrogenase. Horm. Metab. Res.14 (1982) 678–679.

    PubMed  Google Scholar 

  49. Malaisse, W.J., Insulin release: the fuel concept. Diab. Métab.9 (1983) 313–320.

    Google Scholar 

  50. Malaisse, W.J., Basal carbon dioxide output in pancreatic islets. IRCS Med. Sci.11 (1983) 540–541.

    Google Scholar 

  51. Malaisse, W.J., Branched chain amino and keto acids as regulators of insulin and glucagon release, in: Branched chain amino and keto acids in health and disease. Eds S.A. Adibi and P. Schauder. Karger, Basel 1984 (in press).

    Google Scholar 

  52. Malaisse, W.J., Best, L., Kawazu, S., Malaisse-Lagae, F., and Sener, A., The stimulus-secretion coupling of glucose-induced insulin release. Fuel metabolism in islets deprived of exogenous nutrient. Archs Biochem. Biophys.224 (1983) 102–110.

    Article  Google Scholar 

  53. Malaisse, W.J., Deleers, M., Malaisse-Lagae, F., and Sener, A., Anomeric specificity of hexose metabolism in pancreatic islets. Excerpta Medica ICS600 (1982) 345–351.

    Google Scholar 

  54. Malaisse, W.J., Hutton, J.C., Kawazu, S., Herchuelz, A., Valverde, I., and Sener, A., The stimulus-secretion coupling of glucose-induced insulin release. XXXV. The links between metabolic and cationic events. Diabetologia16 (1979) 331–341.

    PubMed  Google Scholar 

  55. Malaisse, W.J., Hutton, J.C., Kawazu, S., and Sener, A., The stimulus-secretion coupling of glucose-induced insulin release. Metabolic effects of menadione in isolated islets. Eur. J. Biochem.87 (1978) 121–130.

    Article  PubMed  Google Scholar 

  56. Malaisse, W.J., Levy, J., Sener, A., and Herchuelz, A., The stimulus-secretion coupling of glucose-induced insulin release. XXII. Qualitative and quantitative aspects of glycolysis in isolated islets. Acta diabetol. lat.13 (1976) 202–215.

    PubMed  Google Scholar 

  57. Malaisse, W.J., Malaisse-Lagae, F., and Mayhew, D., A possible role for the adenylate cyclase system in insulin secretion. J. clin. Invest.46 (1967) 1724–1734.

    PubMed  Google Scholar 

  58. Malaisse, W.J., Malaisse-Lagae, F., and Sener, A., Glucose-induced accumulation of fructose-2,6-bisphosphate in pancreatic islets. Diabetes31 (1982) 90–93.

    PubMed  Google Scholar 

  59. Malaisse, W.J., Malaisse-Lagae, F., and Sener, A., The glycolytic cascade in pancreatic islets. Diabetologia23 (1982) 1–5.

    Article  PubMed  Google Scholar 

  60. Malaisse, W.J., Malaisse-Lagae, F., and Sener, A., Anomeric specificity of hexose metabolism in pancreatic islets. Physiol. Rev.63 (1983) 773–786.

    PubMed  Google Scholar 

  61. Malaisse, W.J., Malaisse-Lagae, F., and Sener, A., Coupling factors in nutrient-induced insulin release. Experientia40 (1984) 1035–1043.

    PubMed  Google Scholar 

  62. Malaisse, W.J., Malaisse-Lagae, F., Sener, A., Van Schaftingen, E., and Hers, H.-G., Is the glucose-induced stimulation of glycolysis in pancreatic islets attributable to activation of phosphofructokinase by fructose-2,6-bisphosphate? FEBS Lett.125 (1981) 217–219.

    Article  PubMed  Google Scholar 

  63. Malaisse, W.J., Sener, A., Carpinelli, A.R., Anjaneyulu, K., Lebrun, P., Herchuelz, A., and Christophe, J., The stimulus-secretion coupling of glucose-induced insulin release. XLVI. Physiological role of L-glutamine as a fuel for pancreatic islets. Molec. cell. Endocr.20 (1980) 171–189.

    Article  PubMed  Google Scholar 

  64. Malaisse, W.J., Sener, A., Herchuelz, A., and Hutton, J.C., Insulin release: the fuel hypothesis. Metabolism28 (1979) 373–386.

    Article  PubMed  Google Scholar 

  65. Malaisse, W.J., Sener, A., Koser, M., and Herchuelz, A., Stimulus-secretion coupling of glucose-induced insulin release. XXIV. Metabolism of alpha- and beta-D-glucose in isolated islets. J. biol. Chem.251 (1976) 5936–5943.

    PubMed  Google Scholar 

  66. Malaisse, W.J., Sener, A., Koser, M., Ravazzola, M., and Malaisse-Lagae, F., The stimulus-secretion coupling of glucose-induced insulin release. Insulin release due to glycogenolysis in glucose-deprived islets. Biochem. J.164 (1977) 447–454.

    PubMed  Google Scholar 

  67. Malaisse, W.J., Sener, A., and Levy, J., The stimulus-secretion coupling of glucose-induced insulin release. XXI. Fasting-induced adaptation of key glycolytic enzymes in isolated islets. J. biol. Chem.251 (1976) 1731–1737.

    PubMed  Google Scholar 

  68. Malaisse, W.J., Sener, A., and Mahy, M., The stimulus-secretion coupling of glucose-induced insulin release. XVIII. Sorbitol metabolism in isolated islets. Eur. J. Biochem.47 (1974) 365–370.

    PubMed  Google Scholar 

  69. Malaisse, W.J., Sener, A., Malaisse-Lagae, F., Hutton, J.C., and Christophe, J., The stimulus-secretion coupling of amino acid-induced insulin release. Metabolic interaction of L-glutamine and 2-ketoisocaproate in pancreatic islets. Biochim. biophys. Acta677 (1981) 39–49.

    PubMed  Google Scholar 

  70. Malaisse, W.J., Sener, A., Malaisse-Lagae, F., Welsh, M., Matthews, D.E., Bier, D.M., and Hellerström, C., The stimulus-secretion coupling of amino acid-induced insulin release. Metabolic response of pancreatic islets to L-glutamine and L-leucine. J. biol. Chem.257 (1982) 8731–8737.

    PubMed  Google Scholar 

  71. Malaisse, W.J., Sener, A., Welsh, M., Malaisse-Lagae, F., Hellerström, C., and Christophe, J., Mechanism of 3-phenyl-pyruvate-induced insulin release. Metabolic aspects. Biochem. J.210 (1983) 921–927.

    PubMed  Google Scholar 

  72. Malaisse-Lagae, F., Sener, A., Garcia-Morales, P., Valverde, I., and Malaisse, W.J., The stimulus-secretion coupling of amino acid-induced insulin release. Influence of a nonmetabolized analog of leucine on the metabolism of glutamine in pancreatic islets. J. biol. Chem.257 (1982) 3754–3758.

    PubMed  Google Scholar 

  73. Malaisse-Lagae, F., Sener, A., Hellerström, C., and Malaisse, W.J., Inhibition of fatty acid oxidation and insulin release in rat pancreatic islets. Diabetologia27 (1984) 306A.

    Google Scholar 

  74. Malaisse-Lagae, F., Sener, A., and Malaisse, W.J., Phosphoglucomutase: its role in the response of pancreatic islets to glucose epimers and anomers. Biochimie64 (1982) 1059–1063.

    PubMed  Google Scholar 

  75. Matschinsky, F.M., and Ellerman, J.E., Metabolism of glucose in the islets of Langerhans. J. biol. Chem.243 (1968) 2730–2736.

    PubMed  Google Scholar 

  76. Matschinsky, F.M., Ellerman, J.E., Krzanowski, J., Kotler-Brajtburg, J., Landgraf, R., and Fertel, R., The dual function of glucose in islets of Langerhans. J. biol. Chem.246 (1971) 1007–1011.

    PubMed  Google Scholar 

  77. Matschinsky, F.M., Ellerman, J., Stillings, S., Raybaud, F., Pace, C., and Zawalich, W., Hexoses and insulin secretion, in: Insulin, part 2, pp. 79–114. Eds A. Hasselblatt and F. v. Bruchhausen. Springer-Verlag, Heidelberg 1975.

    Google Scholar 

  78. McDaniel, M.L., Roth, C.E., Fink, C.J., and Lacy, P.E., Effect of anomers of D-glucose on alloxan inhibition of insulin release in isolated perifused pancreatic islets. Endocrinology99 (1976) 535–540.

    PubMed  Google Scholar 

  79. Meglasson, M.D., Burch, P.T., Berner, D.K., Najafi, H., Vogin, A.P., and Matschinsky, F.M., Chromatographic resolution and kinetic characterization of glucokinase from islets of Langerhans. Proc. natl Acad. Sci. USA80 (1983) 85–89.

    PubMed  Google Scholar 

  80. Meglasson, M.D., and Matschinsky, F.M., New perspectives on pancreatic islet glucokinase. Am. J. Physiol.246 (1984) E1-E13.

    PubMed  Google Scholar 

  81. Meglasson, M.D., Schingo, M., and Matschinsky, F.M., Mannose phosphorylation by glucokinase from liver and transplantable insulinoma. Cooperativity and discrimination of anomers. Diabetes32 (1983) 1146–1151.

    PubMed  Google Scholar 

  82. Miwa, I., Okuda, J., Niki, H., and Niki, A., Uptake of radioactive D-glucose anomers by pancreatic islets. J. Biochem.78 (1975) 1109–1111.

    PubMed  Google Scholar 

  83. Montague, M., and Taylor, K.W., Islet-cell metabolism during insulin release. Effects of glucose, citrate, octanoate, tolbutamide, glucagon and theophylline. Biochem. J.115 (1969) 257–262.

    PubMed  Google Scholar 

  84. Morrison, A.D., Winegrad, A.I., Fink, C.J., and Lacy, P.E., Sorbitol synthesis in isolated rat pancreatic islets. Biochem. biophys. Res. Commun.38 (1970) 491–495.

    Article  PubMed  Google Scholar 

  85. Owen, A., Sener, A., and Malaisse, W.J., Stimulus-secretion coupling of glucose-induced insulin release. LI. Divalent cations and ATPase activity in pancreatic islets. Enzyme29 (1983) 2–14.

    PubMed  Google Scholar 

  86. Pace, C.S., Ellerman, J., Hover, B.A., Stillings, S.N., and Matschinsky, F.M., Multiple metabolic functions of glucose in rat pancreatic islets. Diabetes24 (1975) 476–488.

    PubMed  Google Scholar 

  87. Panten, U., and Klein, H., O2 consumption by isolated pancreatic islets, as measured in a microincubation system with a clark-type electrode. Endocrinology111 (1982) 1595–1600.

    PubMed  Google Scholar 

  88. Panten, U., and Langer, J., Mechanism of 3-phenylpyruvate-induced insulin release from isolated pancreatic islets. Biochem. J.198 (1981) 353–356.

    PubMed  Google Scholar 

  89. Randle, P.J., Ashcroft, S.J.H., and Gill, J.R., Carbohydrate metabolism and release of hormones, in: Carbohydrate metabolism and its disorders, pp. 427–447. Eds F. Dickens, P.J. Randle and W.J. Whelan. Academic Press, London and New York 1968.

    Google Scholar 

  90. Rossini, A.A., Cahill, G.F. Jr, Jeanloz, D.A., and Jeanloz, R.W., Anomeric specificity of 3-O-methyl-D-glucopyranose against alloxan diabetes. Science187 (1975) 70–71.

    PubMed  Google Scholar 

  91. Sener, A., Best, L., Malaisse-Lagae, F., and Malaisse, W.J., The stimulus-secretion coupling of amino acid-induced insulin release. Metabolism of L-asparagine in pancreatic islets. Archs Biochem. Biophys.229 (1984) 155–169.

    Article  Google Scholar 

  92. Sener, A., Kawazu, S., and Malaisse, W.J., The stimulus-secretion coupling of glucose-induced insulin release. Metabolism of glucose in K+-deprived islets. Biochem. J.186 (1980) 183–190.

    PubMed  Google Scholar 

  93. Sener, A., Levy, J., and Malaisse, W.J., The stimulus-secretion coupling of glucose-induced insulin release. XXIII. Does glycolysis control calcium transport in the B-cell? Biochem. J.156 (1976) 521–525.

    PubMed  Google Scholar 

  94. Sener, A., and Malaisse, W.J., The metabolism of glucose in pancreatic islets. Diab. Métab.4 (1978) 127–133.

    Google Scholar 

  95. Sener, A., and Malaisse, W.J., L-Leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenase. Nature288 (1980) 187–189.

    Article  PubMed  Google Scholar 

  96. Sener, A., and Malaisse, W.J., The stimulus-secretion coupling of amino acid-induced insulin release: insulinotropic action of branched-chain amino acids at physiological concentrations of glucose and glutamine. Eur. J. clin. Invest.11 (1981) 455–460.

    PubMed  Google Scholar 

  97. Sener, A., Malaisse-Lagae, F., Lebrun, P., Herchuelz, A., Leclercq-Meyer, V., and Malaisse, W.J., Anomeric specificity of D-mannose metabolism in pancreatic islets. Biochem. biophys. Res. Commun.108 (1982) 1567–1573.

    PubMed  Google Scholar 

  98. Sener, A., Malaisse-Lagae, F., and Malaisse, W.J., Stimulation of pancreatic islet metabolism and insulin release by a nonmetabolizable amino acid. Proc. natl Acad. Sci. USA78 (1981) 5460–5464.

    PubMed  Google Scholar 

  99. Sener, A., Malaisse-Lagae, F., Dufrane, S.P., and Malaisse, W.J., The coupling of metabolic to secretory events in pancreatic islets. The cytosolic redox state. Biochem. J.220 (1984) 433–440.

    PubMed  Google Scholar 

  100. Sener, A., Malaisse-Lagae, F., and Malaisse, W.J., Glucose-induced accumulation of glucose-1,6-bisphosphate in pancreatic islets: its possible role in the regulation of glycolysis. Biochem. biophys. Res. Commun.104 (1982) 1033–1040.

    Article  PubMed  Google Scholar 

  101. Sener, A., Malaisse-Lagae, F., and Malaisse, W.J., The stimulussecretion coupling of glucose-induced insulin release. Environmental influence on L-glutamine oxidation in pancreatic islets. Biochem. J.202 (1982) 309–319.

    PubMed  Google Scholar 

  102. Sener, A., Pipeleers, D.G., Levy, J., and Malaisse, W.J., The stimulus-secretion coupling of glucose-induced insulin release. XXVI. Are the secretory and fuel functions of glucose dissociable by iodoacetate? Metabolism27 (1978) 1505–1517.

    PubMed  Google Scholar 

  103. Sener, A., Valverde, I., and Malaisse, W.J., Presence of HCO 3 -activated ATPase in pancreatic islets. FEBS Lett.105 (1979) 40–42.

    Article  PubMed  Google Scholar 

  104. Sener, A., Van Schaftingen, E., Van De Winkel, M., Pipeleers, D.G., Malaisse-Lagae, F., Malaisse, W.J., and Hers, H.-G., Effect of glucose and glucagon upon the fructose 2,6-bisphosphate content of pancreatic islets and purified pancreatic B-cells. A comparison with isolated hepatocytes. Biochem. J.221 (1984) 759–764.

    PubMed  Google Scholar 

  105. Sener, A., Welsh, M., Lebrun, P., Garcia-Morales, P., Saceda, M., Malaisse-Lagae, F., Herchuelz, A., Valverde, I., Hellerström, C., and Malaisse, W.J., Mechanism of 3-phenyl-pyruvate-induced insulin release. Secretory, ionic and oxidative aspects. Biochem. J.210 (1983) 913–919.

    PubMed  Google Scholar 

  106. Snyder, P.J., Kashket, S., and O'Sullivan, J.B., Pentose cycle in isolated islets during glucose-stimulated insulin release. Am. J. Physiol.219 (1970) 876–880.

    PubMed  Google Scholar 

  107. Sugden, M.C., and Ashcroft, S.J.H., Phosphoenolpyruvate in rat pancreatic islets: a possible intracellular trigger of insulin release? Diabetologia13 (1977) 481–486.

    Article  PubMed  Google Scholar 

  108. Täljedal, I.-B., Presence and possible role of glucose 6-phosphatase in mammalian pancreatic islets. Biochem. J.114 (1969) 387–394.

    PubMed  Google Scholar 

  109. Trus, M., Warner, H., and Matschinsky, F.M., Effects of glucose on insulin release and on intermediary metabolism of isolated perifused pancreatic islets from fed and fasted rats. Diabetes29 (1980) 1–14.

    Google Scholar 

  110. Tutwiler, G.F., and Dellevigne, P., Action of the oral hypoglycemic agent 2-tetradecylglycidic acid on hepatic fatty acid oxidation and gluconeogenesis. J. biol. Chem.254 (1979) 2935–2941.

    PubMed  Google Scholar 

  111. Verspohl, E.J., Handel, M., and Ammon, H.P.T., Pentose-phosphate shunt activity of rat pancreatic islets: its dependance on glucose concentration. Endocrinology105 (1979) 1269–1274.

    PubMed  Google Scholar 

  112. Welsh, M., The importance of substrate metabolism in the regulation of insulin release by mouse pancreatic islets. Thesis, Uppsala University 1982.

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Sener, A., Malaisse, W.J. Nutrient metabolism in islet cells. Experientia 40, 1026–1035 (1984). https://doi.org/10.1007/BF01971448

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