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Regulation of acute phase reaction in rat adjuvant arthritis

  • Autoimmune Models of Tissue Destruction
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Conclusion

Local low dose injection of actinomycin D into the inflamed tissue as well as administration of a glucocorticoid antagonist is apparently suitable for investigating the regulation of acute phase reactionin vivo. The acute phase protein synthesis in the liver is apparently triggered by several factors derived from the inflamed tissue, not only by one substance (IL-1).

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References

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Authors and Affiliations

  1. Department of Pharmacology, Section of Pharmacy, Martin Luther University Halle-Wittenberg, Weinbergweg 15, 4050, Halle (S.), German Democratic Republic

    Rüdiger Schade

  2. Department of Pharmacology and Toxicology, Charité, Humboldt University Berlin, Clara-Zetkin-Str. 94, 1080, Berlin, German Democratic Republic

    Rolf Hirschelmann

Authors
  1. Rolf Hirschelmann
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  2. Rüdiger Schade
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Hirschelmann, R., Schade, R. Regulation of acute phase reaction in rat adjuvant arthritis. Agents and Actions 19, 335–336 (1986). https://doi.org/10.1007/BF01971243

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  • DOI: https://doi.org/10.1007/BF01971243

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