Skip to main content
SpringerLink
Log in

Interaction between neutrophils and pig coronary artery increases histamine contractions

  • Histamine and the Gastrointestinal Tract and Cardiovascular System
  • Published:
Agents and Actions Aims and scope Submit manuscript

Abstract

In the present study we investigated the possible role of neutrophils and the endothelium in the induction of hyperreactivity of pig coronary arteries to histamine. Histamine caused a dose-dependent contraction of isolated pig coronary arteries. The maximal contraction to histamine was reduced in preparations from which the endothelium had been removed. Pre-incubation of intact coronary arteries with isolated neutrophils had no influence on the contractile response to histamine. However, when the same experiments were performed with coronary arteries without endothelium, the maximal contraction to histamine was increased. Incubation with scavengers and inhibitors of the enzymes, lipoxygenase or cyclo-oxygenase, provided evidence for a role of lipoxygenase products in the induction of hyperreactivity to histamine by neutrophils in the pig coronary artery.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. A. Maseri,Spasm and dynamic coronary stenoses. J. Cardiovasc. Pharmacol.6, S683-S690 (1984).

    PubMed  Google Scholar 

  2. K. M. Van Benthuysen, I. F. McMurtry and L. D. Horwitz,Reperfusion after acute coronary occlusion in dogs impairs endothelium-dependent relaxation to acetylcholine and augments contractile reactivity in vitro. J. Clin. Invest.79, 265–274 (1987).

    PubMed  Google Scholar 

  3. N. Toda,Is histamine a human coronary vasospastic substance? Trends Pharmacol. Sci.8, 289–290 (1987).

    Google Scholar 

  4. S. Kalsner and R. Richards,Coronary arteries of cardiac patients are hyperreactive and contain stores of amines: a mechanism for coronary spasm. Science223, 1435–1437 (1984).

    PubMed  Google Scholar 

  5. M. Claeys, G. A. A. Kivits, E. Christ-Hazelhof and D. H. Nugteren,Metabolic profile of linoleic acid in porcine leukocytes through the lipoxygenase pathway. Biochim. Biophys. Acta837, 35–51 (1985).

    PubMed  Google Scholar 

  6. S. J. Weiss,Tissue destruction by neutrophils. New Engl. J. Med.320, 365–374 (1989).

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology, Faculty of Pharmacy, University of Utrecht, Catharijnesingel 60, 3511 GH, Utrecht, The Netherlands

    G. A. M. Ten Have & F. P. Nijkamp

  2. Department of Pharmacology, Erasmus University Rotterdam, The Netherlands

    D. van Heuven-Nolsen

Authors
  1. D. van Heuven-Nolsen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. A. M. Ten Have
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. F. P. Nijkamp
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

van Heuven-Nolsen, D., Ten Have, G.A.M. & Nijkamp, F.P. Interaction between neutrophils and pig coronary artery increases histamine contractions. Agents and Actions 30, 195–197 (1990). https://doi.org/10.1007/BF01969036

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01969036

Keywords

Search

Navigation