Abstract
Although the factors involved in the induction of gastric pathology have long been studied, the exact roles of the two histamine receptors in this process are still obscure.
The aim of this study was to evaluate the consequences of the activation of histamine H1- and/or H2-receptors in the pathogenesis of gastric damage and antagonism of these pathological developments by specific antagonists. The following agents were used: histamine as H1- and H2H2-agonis; 2-pyridylethylamine (PEA) and mepyramine as H1-agonist and antagonist; dimaprit and ranitidine as H2-agonist and antagonist.
Intravenous administration of the agonists caused definite gastric damage in rats. Both the antagonists inhibited histamine-induced gastric lesions, but the PEA and dimaprit-induced erosions could be prevented only by giving the specific H1- or H2-antagonist. In conclusion, activation of either H1- or H2-receptors can play a crucial role in the pathogenesis of histamine-induced gastric damage in rats.
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References
P.H. Guth andC.F. Code,Histamine release and gastric mucosal damage, Gastroenterology74, 622–623 (1978).
W.F. Ritchie,Histamine release and gastric mucosal damage, Gastroenterology74, 933 (1978).
C.H. Cho andC.J. Pfeiffer,Gastrointestinal ulceration with guinea-pig in response to dimaprit, histamine and H 1 and H 2 blocking agents, Dig. Dis. Sci.26, 306–311 (1981).
P. Del Soldato, A. Ghiorzi andL. Buarotti,A rat model based on the histamine H 2 receptor activation induced gastric pathology, Pharmacol. Res. Commun.14, 175–185 (1982).
P. Del Soldato andL. Varin, Aspirin, stress and gastric damage: role of prostaglandins, H2 histamine blocking agents and antimuscarinics,International Meeting on Side effects of Anti-Inflammatory Analgesic Drugs, Verona (Italy), September 13–15, 1982.
G.W. Snedecor andW.G. Cochran,Statistical Methods, p. 209, Ames Iowa: The Iowa State University Press 1972.
J.T. Jr. Lichtfield andF. Wilcoxon,A simplified method of evaluating dose-effect experiments, J. Pharmac. exp. Ther.96, 99–113 (1949).
G.J. Durant, R. Ganellin andM.E. Parsons,Chemical differentiation of histamine H 1-and H 2-receptor agonists, J. med Chem.18, 905–909 (1975).
M.E. Parsons, D.A.A. Owen, G.J. Durant andC.R. Ganellin,Dimaprit-[S-[3-(N,N-dimethylamino)-propyl[-iso-thiourea], a highly specific histamine H 2-receptor agonist — Part 1, Pharmacology, Agents and Actions7, 31–37 (1977).
A.S.F. Ash andH.O. Schild,Receptors mediating some actions of histamine, Br. J. Pharmac.27, 427–439 (1966).
M.J. Daly, J.M. Humphray andR. Stables,Some in vitro and in vivo actions of the histamine H 2-receptor antagonist, ranitidine, Br. J. Pharmac.72, 49–54 (1981).
W.L. Burland andJ. Mills, The pathophysiological role of histamine and potential therapeutic uses of H1 and H2 antihistamines. InPharmacology of Histamine Receptors (EdsC.R. Ganellin andM.E. Parsons) Wright PSG, London 1982.
I.H.M. Main andB.J.R. Whittle,A study of the vascular and acid secretory responses of the rat gastric mucosa to histamine, J. Physiol., Lond.257, 407–418 (1976).
H. Petersen andM.I. Grossmann,Stimulation of gastric acid secretion by dimaprit in unanaesthetized rats, Agents and Actions8, 566–567 (1978).
K.D. Rainsford,The biochemical pathology of aspirin-induced gastric damage, Agents and Actions5, 326–344 (1975).
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Del Soldato, P. Studies with specific agonists and antagonists of the role of histamine H1- and H2-receptor activation in the pathogenesis of gastric lesions in rats. Agents and Actions 14, 139–142 (1984). https://doi.org/10.1007/BF01966633
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DOI: https://doi.org/10.1007/BF01966633