Skip to main content
SpringerLink
Log in

Reduction of acute toxicity of cyclophosphamide and X-rays by the new immunomodulating compound BM 12.531

  • Specialia
  • Published:
Experientia Aims and scope Submit manuscript

Summary

BM 12.531, the 2-[2-cyanaziridinyl-(1)]-2-[2-carbamoylaziridinyl-(1)]-propane, (prop. INN Azimexon), reduces significantly the acute toxicity of cyclophosphamide and X-rays in rats and mice, respectively. The leucopenia induced by X-rays was partially compensated by BM 12.531 in rats.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. U. Bicker, DL-PS 110492 (1974).

  2. U. Bicker, Exp. Path.10, 106 (1975).

    CAS  Google Scholar 

  3. U. Bicker and P. Fuhse, Exp. Path.10, 279 (1975).

    CAS  Google Scholar 

  4. U. Bicker, G. Hebold, H. Hindermayr, U. Kampe and M. Thiel, DT-OS 2610 156 (1976).

  5. U. Bicker, IRCS Med. Sci.5, 428 (1977).

    CAS  Google Scholar 

  6. U. Bicker, A.E. Ziegler and G. Hebold, IRCS Med. Sci.5, 299 (1977).

    CAS  Google Scholar 

  7. U. Bicker, G. Hebold and W. Maus, IRCS Med. Sci.5, 389 (1977).

    Google Scholar 

  8. B. Bonfert, U. Bicker, G. Hebold and W. Maus, IRCS Med. Sci.5, 523 (1977).

    Google Scholar 

  9. J.I. Schulz, I. Florentin, C. Bourut, U. Bicker and G. Mathé, IRCS Med. Sci.6, 215 (1978).

    CAS  Google Scholar 

  10. U. Bicker, Cancer Treatment Reports62, 1987 (1978).

    CAS  PubMed  Google Scholar 

  11. U. Bicker, A.E. Ziegler and G. Hebold, J. infect. Dis.139, No 4 (1979).

  12. U. Bicker, G. Hebold, A.E. Ziegler and W. Maus, Exp. Path.15, 49 (1978).

    CAS  Google Scholar 

  13. W. Stucky and J. Vollmar, J. Statist. Comput. Simul.5, 73 (1976).

    Article  Google Scholar 

  14. J.D. Litchfield and F.W. Wilcoxon, J. Pharmac. exp. Ther.96, 99 (1949).

    CAS  Google Scholar 

  15. R. Braun, personal communication (1978).

Download references

Author information

Authors and Affiliations

  1. Department of Experimental Medicine, Boehringer Mannheim GmbH, Sandhofer Strasse 116, D-6800, Mannheim 31, Federal Republic of Germany

    U. Bicker, K. D. Friedberg, G. Hebold & K. Mengel

  2. Institute of Pharmacology and Toxicology of the Chemical Department Mannheim, University Heidelberg, D-6900, Heidelberg, Federal Republic of Germany

    U. Bicker, K. D. Friedberg, G. Hebold & K. Mengel

Authors
  1. U. Bicker
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. D. Friedberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. Hebold
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. K. Mengel
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This work was supported by ‘Schutzkommission beim Bundesministerium des Innern’.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bicker, U., Friedberg, K.D., Hebold, G. et al. Reduction of acute toxicity of cyclophosphamide and X-rays by the new immunomodulating compound BM 12.531. Experientia 35, 1361–1363 (1979). https://doi.org/10.1007/BF01964009

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01964009

Keywords

Search

Navigation