Abstract
The tick-borne fever (TBF) model was used to study the effect of fever on the metabolism of sulfadimidine in goats. During TBF the elimination half-lives were prolonged, and the renal clearance values of sulfadimidine and the majority of its metabolites were markedly diminished compared with those in the uninfected state. During TBF the steady-state levels of the hydroxy metabolites were markedly increased. TBF reduced the extent of hydroxymethylation of the pyrimidine side chain; TBF did not affect acetylation of sulfadimidine. In one goat a progressive accumulation of the metabolites was noticed.
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Nouws, J.F.M., Van Miert, A.S.J.P.A.M., Van Gogh, H. et al. The effect of tick-borne fever on metabolism and renal clearance of sulfadimidine in goats. Pharmaceutisch Weekblad Scientific Edition 9, 91–97 (1987). https://doi.org/10.1007/BF01960742
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DOI: https://doi.org/10.1007/BF01960742