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Cytotoxicity of ethyl methanesulfonate in mice spermatogonia

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Summary

Enumeration of different types of spermatogonia, following a single i.p. administration of different doses of ethyl methanesulfonate in mice, showed that survival of A1–A4 and in spermatogonia is markedly reduced due to cell killing while the remaining types of spermatogonia were affected marginally. The cell killing effect was dose-dependent, and replenishment of these cells was observed by the end of one cycle of the seminiferous epithelium comprising of 8.5 days.

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Authors and Affiliations

  1. Bio-Medical Group, Bhabha Atomic Research Centre, Trombay, 400085, Bombay, India

    D. Bhattacharjee, T. K. Shetty & K. Sundaram

Authors
  1. D. Bhattacharjee
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  2. T. K. Shetty
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  3. K. Sundaram
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Bhattacharjee, D., Shetty, T.K. & Sundaram, K. Cytotoxicity of ethyl methanesulfonate in mice spermatogonia. Experientia 35, 630–631 (1979). https://doi.org/10.1007/BF01960364

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