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N-ethylmaleimide antagonizes stress-induced gastric ulcers in rats

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Summary

N-ethylmaleimide (NEM) 10 or 25 mg/kg b.wt, given s.c. 20 min beforehand, dose-dependently and significantly antagonizes the severity of gastric glandular ulcers produced by restraint at 4°C (stress) for 2 h. These findings suggest that reduced activity of endogenous nonprotein sulfhydryl substances in gastric tissue does not worsen stress-induced ulceration in rat stomachs, unlike the deleterious effect its depletion is claimed to have on ethanol-evoked gastric mucosal damage. Thus, decreased SH activity appears not to play a role in the aetiology of mucosal ulcers due to stress.

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References

  1. Szabo, S., Trier, J. S., and Frankel, P. W., Science214 (1981) 200.

    Article  CAS  PubMed  Google Scholar 

  2. Evangelista, S., and Meli, A., Dig. Dis. Sci.33 (1988) 1338.

    Article  CAS  PubMed  Google Scholar 

  3. Poon, Y. K., Cho, C. H., and Ogle, C. W., J. Pharm. Pharmac.41 (1989) 563.

    Article  CAS  Google Scholar 

  4. Szabo, S., Maull, E., and Movahedi, S., Gastroenterology80 (1981) 1298A.

    Google Scholar 

  5. Dupuy, D., and Szabo, S., Gastroenterology91 (1986) 966.

    Article  CAS  PubMed  Google Scholar 

  6. Szelenyi, I., and Brune, K., Dig. Dis. Sci.31 (1986) 1207.

    Article  CAS  PubMed  Google Scholar 

  7. Rogers, C., Brown, A., and Szabo, S., Dig. Dis. Sci.33 (1988) 324.

    Article  CAS  PubMed  Google Scholar 

  8. Robert, A., Eberle, D., and Kaplowitz, N., Am. J. Physiol.247 (1984) 296.

    Google Scholar 

  9. Lu, S. C., Kuhlenkamp, J., Robert, A., and Kaplowitz, N., Pharmacology38 (1989) 57.

    Article  CAS  PubMed  Google Scholar 

  10. Szabo, S., Klin. Wochenschr.64 (1986) 116.

    CAS  PubMed  Google Scholar 

  11. Szabo, S., and Szelenyi, I., Trends pharmac. Sci.8 (1987) 149.

    Article  CAS  Google Scholar 

  12. Takeuchi, K., Okada, M., Niida, H., and Okabe, S., J. Pharmac. exp. Ther.248 (1989) 836.

    CAS  Google Scholar 

  13. Dai, S. and Ogle, C. W., Pflügers Arch.336 (1972) 111.

    Article  CAS  PubMed  Google Scholar 

  14. Senay, E. C., and Levine, R. J., Proc. Soc. exp. Biol. Med.124 (1967) 1221.

    Article  CAS  PubMed  Google Scholar 

  15. Cho, C. H., and Ogle, C. W., Eur. J. Pharmac.55 (1979) 23.

    Article  CAS  Google Scholar 

  16. Armitage, P., Statistical Methods in Medical Research. Blackwell Scientific Publications, Oxford and Edinburgh 1971.

    Google Scholar 

  17. Berry, C. N., and Lloyd, K. G., Br. J. Pharmac.90 (1987) 54P.

    Google Scholar 

  18. Ogle, C. W., and Cho, C. H., Eur. J. Pharmac.112 (1985) 285.

    Article  CAS  Google Scholar 

  19. Ogle, C. W., Cho, C. H., and Dai, S., Agents Actions17 (1985) 153.

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Pharmacology, Faculty of Medicine, University of Hong Kong, 5 Sassoon Road, Hong Kong, Hong Kong

    G. P. Garg, C. H. Cho & C. W. Ogle

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  1. G. P. Garg
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  2. C. H. Cho
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  3. C. W. Ogle
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Garg, G.P., Cho, C.H. & Ogle, C.W. N-ethylmaleimide antagonizes stress-induced gastric ulcers in rats. Experientia 47, 250–251 (1991). https://doi.org/10.1007/BF01958150

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  • DOI: https://doi.org/10.1007/BF01958150

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