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The fatty acid composition of banked human milk and infant formulas: The choices of milk for feeding preterm infants

  • Nutrition
  • Original Paper
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Abstract

The fatty acid composition of 48 samples of banked human milk for preterm infants and four standard infants formulas available in Finland were analysed by capillary gas liquid chromatography. The banked milk was collected from mothers who had given birth 0–8 weeks previously. Saturated fatty acids accounted for approximately 50% of the fatty acids in both human milk and the formulas, while the relative content of monoenoic fatty acids tended to be higher in human milk than in the formulas. The relative content of 18∶2n−6 was higher in the formulas (range 14.7%–23.2%) than in human milk (median 9.1%, range 6.3%–13.4%). Fat of banked human milk contained 0.9% and 0.7% polyunsaturated fatty acids with 20 and 22 carbon atoms (LCP), respectively, which is comparable to that of fresh mature human milk. In contrast, LCP could not be detected in any of the formulas. Conclusion: Banked human milk is a good source of LCP and offers a good alternative to LCP containing formulas.

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Abbreviations

LCP :

long-chain polyunsaturated fatty acids

References

  1. Boersma ER, Offringa PJ, Muskiet FAJ, Chase WM, Simmons IJ (1991) Vitamin E, lipid fractions, and fatty acid composition of colostrum, transitional milk, and mature milk: an international comparative study. Am J Clin Nutr 53:1197–1204

    Google Scholar 

  2. Carlson SE, Rhodes PG, Ferguson MG (1986) Docosahexaenoic acid status of preterm infants at birth and following feeding with human milk or formula. Am J Clin Nutr 44:798–804

    Google Scholar 

  3. Clandinin MT, Chappel JE, Leong S, Heim T, Swyer PR, Change GW (1980) Intrauterine fatty acid accretion rates in human brain: implications for fatty acid requirements. Early Hum Dev 4:121–129

    Google Scholar 

  4. Clandinin MT, Chappel JE, Heim T, Swyer PR, Chance GW (1981) Fatty acid utilization in perinatal de novo synthesis of tissues. Early Hum Dev 5:355–366

    Google Scholar 

  5. Clandinin MT, Parrott A, Van Aerde JE, Hervada AR, Lien E (1992) Feeding preterm infants a formula containing C20 and C22 fatty acids simulates plasma phospholipid fatty acid composition of infants fed human milk. Early Hum Dev 31:41–51

    Google Scholar 

  6. Espgan Committee on Nutrition (1991) Comment on the content and composition of lipids in infant formulas. Acta Paediatr Scand 80:887–896

    Google Scholar 

  7. Farquharson J, Cockburn F, Patrick WA, Jamieson EC, Logan RW (1992) Infant cerebral cortex phospholipid fatty-acid composition and diet. Lancet 340:810–813

    Google Scholar 

  8. Folch J, Lees M, Sloane Stanley GH (1957) A simple method for the isolation and purification of total lipides from animal tissue. J Biol Chem 226:497–509

    Google Scholar 

  9. Koletzko B, Bremer HJ (1989) Fat content and fatty acid composition of infant formulas. Acta Paediatr Scand 78:513–521

    Google Scholar 

  10. Koletzko B, Mrotzek M, Bremer HJ (1988) Fatty acid composition of mature human milk in Germany. Am J Clin Nutr 47:954–959

    Google Scholar 

  11. Koletzko B, Schmidt E, Bremer HJ, Haug M, Harzer G (1989) Effects of dietary long-chain polyunsaturated fatty acids on the essential fatty acid status of premature infants. Eur J Pediatr 148:669–675

    Google Scholar 

  12. Luukkainen P, Salo MK, Nikkari T (1994) Changes in the fatty acid composition of preterm and term human milk from one week to six months of lactation. J Pediatr Gastroenterol Nutr 18:355–360

    Google Scholar 

  13. Neuringer M, Connor WE, Lin DS, Barstad L, Luck S (1986) Biochemical and functional effects of prenatal and postnatal ω3 fatty acid deficiency on retina and brain in rhesus monkeys. Proc Natl Acad Sci USA 83:4021–4025

    Google Scholar 

  14. Ponder DL, Innis SM, Benson JD, Siegman JS (1992) Docosahexaenoic acid status of term infants fed breast milk or infant formula containing soy oil or corn oil. Pediatr Res 32:683–688

    Google Scholar 

  15. Ruyle M, Connor WE, Anderson GJ, Lowensohn RI (1990) Placental transfer of essential fatty acids in humans: venous-arterial difference for docosahexaenoic acid in fetal umbilical erythrocytes. Proc Natl Acad Sci USA 87:7902–7906

    Google Scholar 

  16. Uauy RD, Birch DG, Birch EE, Tyson JE, Hoffman DR (1990) Effect of dietary omega-3 fatty acids on retinal function of very-low-birth-weight neonates. Pediatr Res 28:485–492

    Google Scholar 

  17. Vuori E, Kiuru K, Mäkinen SM, Väyrynen P, Kara R, Kuitunen P (1982) Maternal diet and fatty acid pattern of breast milk. Acta Paediatr Scand 71:959–963

    Google Scholar 

  18. Zoeren-Grobben D van, Moison RMW, Ester WM, Berger HM (1993) Lipid peroxidation in human milk and infant formula: effect of storage, tube feeding and exposure to phototherapy. Acta Paediatr 82:645–649

    Google Scholar 

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Luukkainen, P., Salo, M.K. & Nikkari, T. The fatty acid composition of banked human milk and infant formulas: The choices of milk for feeding preterm infants. Eur J Pediatr 154, 316–319 (1995). https://doi.org/10.1007/BF01957370

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  • DOI: https://doi.org/10.1007/BF01957370

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