Summary
A series of microiontophoretic and VTA stimulation experiments, conducted in intact, GBR-12909-treated, α-methylparatyrosine-depleted or 6-hydroxydopamine-denervated rats, provide suggestive evidence for the existence of a presynaptic, positive feedback mechanism triggered by dopamine reuptake and favoring the release of this transmitter in the anterior cingulate cortex.
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Acknowledgments. The authors are grateful to Ms Sylvie Gagné for technical assistance and Messrs Daniel Cyr, Giovanni Battista Filosi and Claude Gauthier for photographic and graphic work. They also thank Dr Jean-Claude Lacaille for a critical revision of the manuscript. This study was supported by an operating grant (A.F.) and a Studentship (M.B.) from the Medical Research Council of Canada.
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Beauregard, M., Ferron, A. & Descarries, L. Possible existence of a presynaptic positive feedback mechanism enhancing dopamine transmission in the anterior cingulate cortex of the rat. Experientia 45, 888–892 (1989). https://doi.org/10.1007/BF01954066
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DOI: https://doi.org/10.1007/BF01954066