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Dissociation of separate mechanisms of estrogen action by actinomycin D

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Summary

Pretreatment with actinomycin D 1 h before estrogen administration completely blocks estrogen-induced increases in uterine RNA and protein content, but does not counteract estrogen-induced uterine eosinophilia, edema and increase in glycogen content.

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Authors and Affiliations

  1. Laboratory of Experimental Endocrinology, Department of Experimental Morphology, University of Chile Medical School at Santiago Norte, Casilla 21104, Correo 21, Santiago, Chile

    A. N. Tchernitchin & P. Galand

  2. Biology Unit, Institute of Interdisciplinary Research, Free University of Brussels Medical School, 2, rue Evers, B-1000, Brussels, Belgium

    A. N. Tchernitchin & P. Galand

Authors
  1. A. N. Tchernitchin
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  2. P. Galand
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Additional information

Acknowledgments. This work was supported by the Belgian Ministry of Scientific Policy (Concerted Actions of Research) and by the Servicio de Desarrollo Cientifico, Artistico y de Cooperacion Internacional from the University of Chile.

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Tchernitchin, A.N., Galand, P. Dissociation of separate mechanisms of estrogen action by actinomycin D. Experientia 38, 511–513 (1982). https://doi.org/10.1007/BF01952668

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