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Stimulation of H+ ion secretion from the isolated mouse stomach by sodium fluoride

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Summary

The effect of sodium fluoride on H+ ion secretion was investigated in the isolated distended mouse stomach. It was found that sodium fluoride on its own caused dose-related stimulation of H+ ion secretion. Sodium fluoride did not inhibit H+ ion secretion induced by histamine. The possible mechanisms involved are discussed. It is considered that sodium fluoride might stimulate H+ ion secretion by causing histamine release and by increasing cyclic AMP formation in the intact gastric mucosa.

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Author notes

  1. B. Y. C. Wan

    Present address: Department of Pharmacology, Biorex Research Laboratories Ltd, Canonbury Villas, N1 2HB, London, England

Authors and Affiliations

  1. Department of Pharmacology, University College London, Gower Street, WC1E 6BT, London, England

    B. Y. C. Wan

  2. Department of Pharmacology, Biorex Research Laboratories Ltd, Canonbury Villas, N1 2HB, London, England

    E. S. K. Assem

Authors
  1. E. S. K. Assem
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  2. B. Y. C. Wan
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Assem, E.S.K., Wan, B.Y.C. Stimulation of H+ ion secretion from the isolated mouse stomach by sodium fluoride. Experientia 38, 369–370 (1982). https://doi.org/10.1007/BF01949398

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  • DOI: https://doi.org/10.1007/BF01949398

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