Zusammenfassung
Rasche Metabolisierung und Ausscheidung sowie Eliminierung von Thebain im Rattenhirn verursacht keine biochemische Änderung der Zellen im Zentralnervensystem, woraus die geringe physiologische Gewöhnung resultieren dürfte.
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Misra, A.L., Pontani, R.B. & Mule, S.J. Relationship of pharmacokinetic and metabolic parameters to the absence of physical dependence liability with thebaine-3H. Experientia 29, 1108–1110 (1973). https://doi.org/10.1007/BF01946748
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DOI: https://doi.org/10.1007/BF01946748