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Influence of buprenorphine on acute experimental pancreatitis

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Research in Experimental Medicine

Summary

Buprenorphine (15 µg/kg b.wt. per hour) distinctly reduced pain sensitivity in acute 3% sodium-taurocholate pancreatitis in male Wistar rats without interfering with the course of the disease. This was seen by assessment of enzyme elevation in serum and ascites and by histological evaluation of the pancreas. Buprenorphine is therefore recommended for animal experiments to study the effect of therapeutic principles in acute pancreatitis.

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Author notes

  1. U. Wereszczyńska-Siemiatkowska

    Present address: Paristwowy Szpital Kliniczny, Klinika Gastroenterologii, ul. M. Sklodowskiej-Curie 24a, PL-15-276, Bialystok, Poland

  2. P. G. Lankisch

    Present address: Medizinische Abt., Städtisches Krankenhaus, Bögelstr. 1, D-2120, Lüneburg, Federal Republic of Germany

Authors and Affiliations

  1. Division of Gastroenterology and Metabolism, Dept. of Internal Medicine, University of Göttingen, Göttingen, Federal Republic of Germany

    U. Wereszczyńska-Siemiatkowska, U. Pohl, J. Otto, H. Wilms & P. G. Lankisch

  2. Dept. of Experimental Animal Research, University of Göttingen, Göttingen, Federal Republic of Germany

    K. Nebendahl

  3. Dept. of Pathology, University of Göttingen, Göttingen, Federal Republic of Germany

    H. -J. Groene

Authors
  1. U. Wereszczyńska-Siemiatkowska
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  2. K. Nebendahl
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  3. U. Pohl
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  4. J. Otto
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  5. H. -J. Groene
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  6. H. Wilms
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  7. P. G. Lankisch
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Wereszczyńska-Siemiatkowska, U., Nebendahl, K., Pohl, U. et al. Influence of buprenorphine on acute experimental pancreatitis. Res. Exp. Med. 187, 211–216 (1987). https://doi.org/10.1007/BF01852085

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  • DOI: https://doi.org/10.1007/BF01852085

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