Skip to main content
SpringerLink
Log in

Carbohydrate metabolism after three months of using a gestodene-containing monophasic oral contraceptive

  • Published:
Advances in Contraception

Abstract

Carbohydrate metabolism was prospectively evaluated in twenty-one normal women prior to and during their use for three months of a monophasic oral contraceptive containing the progestin gestodene plus ethinyl estradiol. The women had a three-hour oral glucose tolerance test using a 75 gram glucose load, measuring serum glucose and insulin levels. The results demonstrate no significant changes in either of the carbohydrate metabolic indices between the two tests. These data support the safety of this new progestin-containing contraceptive.

Resumé

Une étude prospective a été effectuée pour évaluer le métabolisme des hydrates de carbone chez vingt et une femmes normales avant de pendant un traitement de trois mois avec un contraceptif oral monophasique contenant du gestodène-progestérone, plus de l'éthinyl oestradiol. Ces femmes ont été soumises à un test de trois heures orale à raison de 75 grammes. Au cours de ce test, on a mesuré les niveaux de glucose sérique et d'insuline. Les résultats n'ont pas révélé de changements significatifs des indices métaboliques des hydrates de carbone entre les deux tests, ce qui vient confirmer la sécurité de ce nouveau contraceptif aux hormones progestatives.

Resumen

Se realizó un estudio prospectivo a los efectos de evaluar el metabolismo de los hidratos de carbono en veintiún mujeres normales antes de y durante un tratamiento de tres meses con un anticonceptivo oral monofásico que contenía gestodén-progesterona además de etinil estradiol. Las mujeres fueron sometidas a un análisis de tres horas para medir la tolerancia a la glucosa administrada por vía oral a razón de 75 gramos. En el curso de este análisis se midieron los niveles de seroglucosa y de insulina. Los resultados no revelaron cambios significativos de los índice metabólicos de los hidratos de carbono entre los dos análisis. Estos datos corroboran la seguridad de este nuevo anticonceptivo con progesterona.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. SpellacyW.N. (1976). Carbohydrate metabolism in male infertility and female fertility-control patients.Fertil. Steril.,27, 1132–41.

    PubMed  Google Scholar 

  2. DudleyR.A., EdwardsP., EkinsR.P., FinneyD.J., McKenziyI.G.M., RaabG.M., RodbardD. and FlodgersR.P.C. (1985). Guidelines for immunoassay data processing.Clin. Chem.,31, 1264–71.

    PubMed  Google Scholar 

  3. PollowK., JuchemM., GrillH.J., ElgerW., BeierS., HendersonD., Schmidt-GollwitzerK. and ManzB. (1989). Gestodene: a novel synthetic progestin-characterization of binding to receptor and serum proteins.Contraception,40, 325–41.

    PubMed  Google Scholar 

  4. PhillipsA., DemarestK., HahnD.W., WongF. and McGuireJ.L. (1990). Progestational and androgen receptor binding affinities andin vivo activities of norgestinate and other progestins.Contraception,41, 399–406.

    PubMed  Google Scholar 

  5. BallM.J., AshwellE., JacksonM. and GillmerM.D.G. (1990). Comparison of two triphasic contraceptives with different progestogens: effects on metabolism and coagulation proteins.Contraception,41, 363–76.

    PubMed  Google Scholar 

  6. MiccoliR., OrlandiM.C., FruzzettiF., GiampietroO., MelisG., RicciC., BertolottoA., FiorettiP. and NavalesiR. (1989). Metabolic effects of three new low-dose pills: a six month experience.Contraception,39, 643–52.

    PubMed  Google Scholar 

  7. MiccoliR., OrlandiM.C., FruzzettiF., MelisG.B., GiampietroO., RicciC., BertolottoA., MasoniA., PennoG., FiorettiP. and NavalesiR. (1989). Effetti dei contraccettivi orali a basse dosi sul metabolismo glucidico.Minerva Ginecol.,41, 441–4

    PubMed  Google Scholar 

  8. Van derVangeN., KlooslerboerH.J. and HaspelsA.A. (1987). Effect of seven low-dose combined oral contraceptive preparations on carbohydrate metabolism.Am. J. Obstet. Gynecol.,156, 918–22

    PubMed  Google Scholar 

  9. FiorettiP., FruzzettiF., NavalesiR., RicciC., MiccoliR., CerriM. and MelisG.B. (1989). Clinical and metabolic effects of a pill containing 30 μg ethinyl estradiol plus 75 μg gestodene.Contraception,40, 649–63.

    PubMed  Google Scholar 

  10. RunnebaumB. and RabeT. (1989). Neue Gestagene in oralen hormonalen kontrazeptiva.Arch. Gynec. Obst.,245, 1000–5

    Google Scholar 

  11. TrossarelliG.F., BordonR., GennarelliG.L. and CartaQ. (1991). An open prospective study on the effects on carbohydrate metabolism of an oral monophasic contraceptive containing gestodene (WL-70).Contraception,43, 423–30

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, University of South Florida College of Medicine, 4 Columbia Drive, 33606, Tampa, Florida, USA

    W. N. Spellacy, R. A. Schwandt, J. C. M. Tsibris, S. Smalling, R. A. Chez, J. L. Angel & W. F. O'Brien

Authors
  1. W. N. Spellacy
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. A. Schwandt
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. C. M. Tsibris
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. Smalling
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. R. A. Chez
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. J. L. Angel
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. W. F. O'Brien
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Spellacy, W.N., Schwandt, R.A., Tsibris, J.C.M. et al. Carbohydrate metabolism after three months of using a gestodene-containing monophasic oral contraceptive. Adv Contracept 8, 21–26 (1992). https://doi.org/10.1007/BF01849344

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01849344

Keywords

Search

Navigation