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Potential application of inhibin in male and female contraception

  • Published:
Advances in Contraception

Abstract

After a review of investigations into the possible use of inhibin in the regulation of male and female fertility, briefly described and summarized in this article, the authors conclude that, at least in experimental animals, inhibin causes a significant reduction in testicular and epididymal spermatozoa in the male and luteal phase defect in the female. The precise mechanism by which inhibin brings about these effects is not known at present, and its elucidation will greatly help in the more effective use of inhibin.

Resumé

Cet article décrit brièvement et résume les voies d'investigation à suivre pour pouvoir envisager l'usage de l'inhibine comme contraceptif chez l'homme et chez la femme. La conclusion des auteurs est que l'inhibine provoque, du moins chezl' animal de laboratoire, une importante diminution du nombre des spermatozoïdes testiculaires et épididymaux chez le mâle, et un défaut de la phase lutéale chez la femme. On ignore actuellement le mécanisme précis par lequel l'inhibine produit ces effets; lorsque cette question sera élucidée, l'usage de l'inhibine n'en sera que plus efficace.

Resumen

Luego de revisar las investigaciones hechas sobre el posible uso de la inhibina en la regulación de la fertilidad masculina y femenina, brevemente descritas y resumidas en este artículo, los autores determinan que, al menos en animales de experimentación, la inhibina provoca una reducción en los espermatozoides testiculares y epididimarios en el macho y defecto en la fase luteal en la hembra. Al presente no se conoce el mecanismo exacto por el cual la inhibina provoca estos efectos y su elucidación será de gran ayuda para su uso mas efectivo.

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Authors and Affiliations

  1. Institute for Research in Reproduction (ICMR), Jehangir Merwanji Street, Parel, 400 012, Bombay, India

    A. R. Sheth & S. B. Moodbidri

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  1. A. R. Sheth
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  2. S. B. Moodbidri
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Sheth, A.R., Moodbidri, S.B. Potential application of inhibin in male and female contraception. Adv Contracept 2, 131–139 (1986). https://doi.org/10.1007/BF01849222

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  • DOI: https://doi.org/10.1007/BF01849222

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