Summary
This study was performed to determine the effects of osmotic and oncodiuretic therapy on CT-brain density (CT-BD) and on intracranial pressure (ICP) in normal monkeys. CT scans were obtained before therapy then hourly for six hours. ICP was measured before therapy and was continuously monitored thereafter. Four monkeys in group I received oncodiuretic therapy (furosemide-albumin) for the first five hours, then osmotic therapy (mannitol) was added for one hour. Four monkeys in group II received mannitol during the first hour of therapy, then oncodiuretic therapy was added for the remaining four hours. CT-BD was increased and ICP decreased one hour after mannitol but not after oncodiuretic therapy. CT-BD and ICP correlated inversely during osmotic therapy but not during oncodiuretic therapy. The effects of mannitol on CT-BD indicate that it lowers ICP by dehydrating normal brain. Oncodiuretic therapy did not reduce ICP nor consistently increase CT-BD in these six hour experiments on monkeys without cerebral oedema.
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Albright, A. L., Latchaw, R. E., Robinson, A. G., Intracranial and systemic effects of osmotic and oncotic therapy in experimental cerebral edema. J. Neurosurg.60 (1984), 481–489.
Cascino, T., Baglivo, J., Conti, J., Szewczykowski, J., Posner, J. B., Rottenberg, D. A., Quantitative CT assessment of furosemide- and mannitol-induced changes in brain water content. Neurology33 (1983), 898–903.
Clasen, R. A., Cooke, P. M., Pandolfi, S., Carnecki, G., Bryar, G., Hypertonic urea in experimental cerebral edema. Arch. Neurol.12 (1965), 424–434.
Langfitt, T. W., Increased intracranial pressure and the cerebral circulation. In: Neurological Surgery, Ed. 2, Vol. 2 (Youmans, J. R., ed.), pp. 905–910. Philadelphia: W. B. Saunders. 1982.
Muizelaar, J. P., Wei, E. P., Kontos, H. A., Becker, D. P., Mannitol causes compensatory cerebral vasoconstriction and vasodilatation in response to blood viscosity changes. J. Neurosurg.59 (1983), 822–828.
Rieth, K. G., Fujiwara, K., DiChiro, G., Klatzo, I., Brooks, R. A., Johnson, G. S., O'Connor, C. M., Mitchell, L. G., Serial measurements of CT attenuation and specific gravity in experimental cerebral edema. Radiology135 (1980), 343–348.
Takagi, H., Shapiro, K., Marmarou, A., Wisoff, H., Microgravimetric analysis of human brain tissue. Correlations with computerized tomography scanning. J. Neurosurg.54 (1981), 797–801.
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Albright, A.L., Latchaw, R.E. Effects of osmotic and oncodiuretic therapy on CT-brain density and intracranial pressure. Acta neurochir 78, 119–122 (1985). https://doi.org/10.1007/BF01808690
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DOI: https://doi.org/10.1007/BF01808690